Microstructural Changes in the Cerebral White Matter After 12 Months of CPAP Treatment for Moderate to Severe Obstructive Sleep Apnoea: A TBSS Study

Figures & data

Figure 1 Schematic diagram of OSA patient collection in this study.

Table 1 Demographic and Clinical Data of Pre-CPAP and Post-CPAP

Category	pre-CPAP	post-CPAP	t-value	P-value
Gender(male/female)	16/1	16/1	n/a	n/a
Age(year)^a	41.00±8.58	n/a	n/a	n/a
BMI(Kg/m^2)^b	27.03±4.26	26.68±4.27	0.237	0.814
Education(year)^b	12.17±2.96	n/a	n/a	n/a
AHI^b	44.88±2.35	n/a	n/a	n/a
LSaO2(%)^b	73.82±10.30	n/a	n/a	n/a
MSaO2(%)^b	94.78±2.23	n/a	n/a	n/a
SaO2 <90%^b	31.86±15.7	n/a	n/a	n/a
MoCA^b	23.47±2.83	25.88±2.49	−2.634	0.013
HAMA^b	8.00±5.14	3.52±3.42	2.980	0.005
HAMD^b	5.00±2.73	3.00±2.39	2.265	0.030
PSQI^b	6.05±2.04	4.29±2.17	2.438	0.020
ESS^b	10.41±5.40	5.88±3.63	2.865	0.007

Notes: ^aStudent, t-test; ^bMann–Whitney U-test. n/a indicates the no statistics.

Abbreviations: AHI, apnea hypopnea index; LSaO₂, minimum blood oxygen saturation; MSaO₂, average blood oxygen saturation; SaO₂<90%, percentage of total sleep time with oxygen saturation <90; ESS, Epworth sleepiness scale; HAMA, Hamilton anxiety scale; HAMD, Hamilton depression scale; PSQI, Pittsburgh sleep quality index.

Table 2 Distribution of MD Differences in OSA Patients After 12 Months of CPAP Treatment

Cluster Index	WM	L/R	MNI			Voxels	Base line	Post-Treatment	P-value
			X	Y	Z
1	BCC	L/R	−7	−26	25	10	0.00072±0.00007	0.00057±0.00005	0.049*
2	PLIC	R	23	−6	1	15	0.00068±0.00003	0.00064±0.00003	0.049
3	CG	R	22	−46	−7	24	0.00072±0.00006	0.00059±0.00007	0.05*
4	PLIC, SCR, PCR, PTR	R	28	−32	18	754	0.00073±0.00002	0.00067±0.00004	0.04
5	RLIC, PTR, EC, SLF	R	47	−43	−5	1397	0.00074±0.00003	0.00067±0.00006	0.036

Note: *Results with relevance.

Abbreviations: RLIC, Retrolenticular part of internal capsule; PTR, Posterior thalamic radiation; EC, External capsule; SLF, Superior longitudinal fasciculus; SCR, Superior corona radiata, PCR, Posterior corona radiata; CG, Cingulum; BCC, Body of corpus callosum; PLIC, Posterior limb of internal capsule.

Table 3 Distribution of RD Differences in OSA Patients After 12 Months of CPAP Treatment

Cluster Index	WM	L/R	MNI坐标			Voxels	Base line	Post-Treatment	P-value
			X	Y	Z
1	EC	R	32	−20	1	32	0.00055±0.00004	0.00048±0.00006	0.049
2	RLIC	R	29	−28	2	53	0.00047±0.00003	0.00039±0.00005	0.049
3	CG, ILF	R	22	−46	−7	115	0.00058±0.00007	0.00045±0.00007	0.046*
4	PLIC, SCR, PCR, PTR	R	26	−26	27	190	0.00049±0.00003	0.00043±0.00003	0.046
5	RLIC, EC	R	40	−17	−11	366	0.00057±0.00006	0.00048±0.00006	0.043
6	RLIC, PTR, SLF	R	47	−43	−5	474	0.0005±0.00003	0.0004±0.00006	0.040

Note: *Results with relevance.

Abbreviations: RLIC, Retrolenticular part of internal capsule; PTR, Posterior thalamic radiation; SLF, Superior longitudinal fasciculus; EC, External capsule; SCR, Superior corona radiata; PCR, Posterior corona radiata; PLIC, Posterior limb of internal capsule; CG, Cingulum; ILF, Inferior longitudinal fasciculus.

Figure 2 TBSS analysis of white matter fibres in OSA patients before and after CPAP treatment, green: mean fractional anisotropy (FA) skeleton; blue and red: area of change of DTI values in the OSA group after CPAP treatment (MD and RD), p<0.05.

Figure 3 Correlation of MD and RD values with clinical assessment scales in OSA patients after treatment.

Abbreviations: BCC, body of corpus callosum; CG, Cingulum.