Obstructive Sleep Apnea Syndrome and Obesity Indicators, Circulating Blood Lipid Levels, and Adipokines Levels: A Bidirectional Two-Sample Mendelian Randomization Study

Figures & data

Figure 1 Graphical representation of the MR assumptions.

Table 1 Characteristics of GWAS Consortiums Used for Each Variable

Traits	GWAS Accession Number	Sample Size	Numbers of SNPs	Population	Year
Obesity indicators
BMI	ieu-b-40	681,275	2,336,260	European	2018
BFP	ukb-b-8909	454,633	9,851,867	European	2018
WHR	ieu-b-4830	85,978	7,908,954	European	2022
NC	ebi-a-GCST90017135	8,732	7,756,629	Mixed	2021
Lipid indicators
TG	ieu-b-111	441,016	12,321,875	European	2020
CHOL	ebi-a-GCST90025953	437,878	4,232,052	European	2021
HDL-C	ebi-a-GCST90025956	400,754	4,218,934	European	2021
LDL-C	ebi-a-GCST90002412	431,167	16,293,344	European	2020
ApoA	ukb-d-30630_raw	-	13,585,234	European	2018
ApoB	ukb-d-30640_raw	-	13,585,958	European	2018
Lp(a)	ukb-d-30790_raw	-	13,583,854	European	2018
Adipokines
Interleukin-6	ebi-a-GCST90012005	21,758	11,782,139	European	2020
Interleukin-8	ebi-a-GCST90011994	21,758	12,717,989	European	2020
Adiponectin	ieu-a-1	39,883	2,675,209	Mixed	2012
Leptin	ebi-a-GCST90012076	21,758	13,097,407	European	2020
Leptin receptor	prot-a-1724	3,301	10,534,735	European	2018
Omentin	ebi-a-GCST90085763	400	5,188,525	European	2022
Resistin	ebi-a-GCST90012034	21,758	13,138,697	European	2020
Vaspin	ebi-a-GCST90085786	400	5,188,525	European	2022
RBP4	prot-a-2507	3,301	10,534,735	European	2018
AGRP	ebi-a-GCST90012063	21,758	13,102,571	European	2020
FABP	ebi-a-GCST90012075	21,758	13,138,563	European	2020
OSAS	finn-b-G6_SLEEPAPNO	16,761	16,380,465	European	2021

Table 2 Bidirectional MR Results of Obesity Indicators, Lipid Indicators, Adipokines and OSAS

Exposure	Outcome	No. SNP	IVW or IVW-mre			MR-PRESSO	MR-Egger Intercept Regression	Cochran’s Q Statistic
			Beta	P	OR (95% CI)	P	P	P
OSAS	NC	4	1.244	2.201E-05	3.472 (1.954–6.169)	0.39	0.572	0.32
OSAS	HDL-C	5	−0.101	1.252E-04	0.904 (0.858–0.952)	0.059	0.927	0.001
OSAS	Leptin	5	0.304	0.012	1.355(1.069–1.718)	0.066	0.863	0.006
OSAS	Leptin R	5	−0.319	0.047	0.722(0.530–0.996)	0.764	0.670	0.789

Data Sharing Statement

The datasets underpinning the conclusions drawn in this article are accessible through the IEU OpenGwas project repository. Interested readers and researchers can access these datasets at (https://gwas.mrcieu.ac.uk/).