Drospirenone-containing oral contraceptives and venous thromboembolism: an analysis of the FAERS database

Figures & data

Table 1 MedDRA terms included in the SMQ Embolic and Thrombotic Events, Venous

Venous thrombotic (SMQ) preferred terms
Axillary vein thrombosis	Pulmonary thrombosis
Budd–Chiari syndrome	Pulmonary vein occlusion
Catheterization venous	Pulmonary veno-occlusive disease
Cavernous sinus thrombosis	Pulmonary venous thrombosis
Central venous catheterization	Renal vein embolism
Cerebral venous thrombosis	Renal vein occlusion
Compression stockings application	Renal vein thrombosis
Deep vein thrombosis	Retinal vein occlusion
Deep vein thrombosis postoperative	Retinal vein thrombosis
Embolism venous	SI QIII TIII pattern
Hepatic vein occlusion	Splenic vein occlusion
Hepatic vein thrombosis	Splenic vein thrombosis
Homans’ sign positive	Subclavian vein thrombosis
Iliac vein occlusion	Superior sagittal sinus thrombosis
Inferior vena cava syndrome	Superior vena cava syndrome
Inferior vena caval occlusion	Thrombophlebitis
Intracranial venous sinus thrombosis	Thrombophlebitis migrans
Intravenous catheter management	Thrombophlebitis neonatal
Jugular vein thrombosis	Thrombosed varicose vein
May–Thurner syndrome	Thrombosis corpora cavernosa
Mesenteric vein thrombosis	Transverse sinus thrombosis
Obstetrical pulmonary embolism	Vascular graft
Paget–Schroetter syndrome	Vena cava embolism
Pelvic venous thrombosis	Vena cava filter insertion
Penile vein thrombosis	Vena cava thrombosis
Phlebectomy	Venogram abnormal
Phleboplasty	Venoocclusive disease
Portal vein occlusion	Venoocclusive liver disease
Portal vein thrombosis	Venous occlusion
Postprocedural pulmonary embolism	Venous operation
Postthrombotic syndrome	Venous recanalisation
Postoperative thrombosis	Venous stent insertion
Postpartum venous thrombosis	Venous thrombosis
Pulmonary embolism	Venous thrombosis in pregnancy
Pulmonary infarction	Venous thrombosis limb
Pulmonary microemboli	Venous thrombosis neonatal

Abbreviation: SMQ, Standardized MedDRA Query.

Table 2 Specific drugs included

Progestin	Products
Drospirenone	Drospirenone and Ethinyl Estradiol
	Yasmin
	Yaz
	Ocella
Levonorgestrel	Alesse
	Aviane
	Enpresse
	Lessina
	Levlite
	Levora
	Loseasonique
	Low-ogestrel
	Lybrel
	Nordette
	Portia
	Seasonale
	Seasonique
	Triphasil
	Trivora

Figure 1 IC05 values for drospirenone-containing OCPs and levonorgestrel-containing OCPs.

Abbreviations: OCP, oral contraceptive pills; SMQ, Standardized MedDRA Query.