Contraception for women with epilepsy: counseling, choices, and concerns

Figures & data

Figure 1 Impact of addition and withdrawal of combined oral contraception on lamotrigine (LTG) serum concentration.

Note: Permission is kindly granted by John Wiley & Sons Ltd to adapt data from Sidhu J, Job S, Singh S, Philipson R. The pharmacokinetic and pharmacodynamic consequences of the co-administration of lamotrigine and a combined oral contraceptive in healthy female subjects. Br J Clin Pharmacol. 2006;61(2):191–199.⁵³ (c) 2005 Blackwell Publishing Ltd.
Abbreviation: COC, combined oral contraceptive; mono, monotherapy.

Table 1 Pharmacokinetic interactions between HC and AEDs

	AED reduced by EE	EE reduced by AED	Progestin reduced by AED
Old AEDs
Carbamazepine	NA	Yes	Yes
Phenobarbital	NA	Yes	Yes
Phenytoin	NA	Yes	Yes
Valproate	Yes	No	No
New AEDs
Eslicarbazepine	NA	Yes	Yes
Felbamate	NA	Yes	Yes
Gabapentin	NA	No	No
Lacosamide	No	No	No
Lamotrigine	Yes	No	Yes
Levetiracetam	No	No	No
Oxcarbazepine	NA	Yes	Yes
Perampanel	NA	No	Yesa
Pregabalin	NA	NA	NA
Retigabine/Ezogabine	No	No	No
Rufinamide	No	Yes	Yes
Stiripentol	NA	NA	NA
Topiramate	NA	Yesa	No
Zonisamide	No	No	No

Note:

a Dose dependent.

Abbreviations: HC, hormonal contraception; AED, antiepileptic drug; EE, ethinyl estradiol; NA, no data available.

SidhuJJobSSinghSPhilipsonRThe pharmacokinetic and pharmacodynamic consequences of the co-administration of lamotrigine and a combined oral contraceptive in healthy female subjectsBr J Clin Pharmacol200661219119916433873

 PubMed Web of Science ®Google Scholar