Fatigue in Saudi Patients with Primary Sjögren’s Syndrome and Its Correlation with Disease Characteristics and Outcome Measures: A Cross-Sectional Study

Figures & data

Table 1 Present Patient Demographics, Laboratory Variable and Outcome Measures are Presented as Means (±SD) and Percentages

Demographics	n=41
Female gender, n (%)	32 (78%)
Age at diagnosis, y ±SD	54.8±13.4
Age at study inclusion, y ±SD	58.76±12.7
Disease duration, y ±SD	4.6±2.28
Presence of EGM, n(%)	36 (87.8%)
Outcome measures
ESSDAI, mean ±SD	9.95±7.73
ESSPRI, mean ±SD	5.17±2.4
PGA, mean ±SD	5.2±2.37
PhGA, mean ±SD	4.46±2.06
Positive Antibody profile
ANA, n (%)	32 (78%)
Anti-SSA, n (%)	19 (46.3%)
Anti-SSB, n (%)	12 (29.3%)
Rheumatoid Factor, n (%)	10 (24.4%)

Abbreviations: ESSDAI, EULAR Sjogren’s syndrome disease activity index; ESSPRI, EULAR Sjogren’s syndrome patient reported outcome; PGA, patient global assessment; PhGA, physician global assessment.

Figure 1 Graphical representation of mean values of the fatigue severity score sub-scores with a radar chart in patients who scored positive (solid lines) and negative (dashed lines).Q1 My motivation is lower when I am fatigued, Q2 Exercise brings on my fatigue, Q3 I am easily fatigued, Q4 Fatigue interferes with my physical functioning, Q5 Fatigue causes frequent problems for me, Q6 My fatigue prevents sustained physical functioning, Q7 Fatigue interferes with carrying out certain duties and responsibilities, Q8 Fatigue is among my most disabling symptoms, Q9 Fatigue interferes with my work, family, or social life.

Figure 2 The statistical correlation between the fatigue severity score and disease-related measures using the Spearman correlation with solid line representing a statistically significant correlation (p<0.05) and the dashed line representing a non-significant correlation.

Abbreviations: FSS, fatigue severity score; ESSDAI, EULAR Sjögren’s syndrome disease activity index; ESSPRI, EULAR Sjögren’s syndrome patient reported outcome; PGA, patient global assessment; PhGA, physician global assessment.