Orphan drugs for sickle vaso-occlusion: dawn of a new era of targeted treatment

Figures & data

Figure 1 Pathophysiology of sickle vaso-occlusion.

Figure 2 Acute and chronic complications of sickle cell disease (SCD).

Figure 3 Competing effects of hemoglobin in sickle cell disease pathophysiology.

Figure 4 Therapeutic targets and corresponding investigation agents in sickle cell disease.