Safety and efficacy of a growth factor and cytokine-containing topical product in wound healing and incision scar management after upper eyelid blepharoplasty: a prospective split-face study

Figures & data

Table 1 Subjects self-assessment of the eyelid scar and overall appearance. The patients were asked to choose which eyelid had a better appearance

	Treated eyelids looked better	Control eyelids looked better	Both eyelids similar	P-value*
Week 2
Scar appearance	10	3	7	0.92
Overall appearance	9	6	5	0.61
Week 6
Scar appearance	11	3	6	0.057
Overall appearance	13	3	4	0.021
Week 10
Scar appearance	14	1	5	0.001
Overall appearance	14	1	5	0.001
Week 14
Scar appearance	13	3	4	0.021
Overall appearance	11	1	8	0.006

Note:

* McNemar’s test.

Figure 1 Eyelid appearance and scar in a representative patient.

Notes: Top row (before surgery) and bottom row (10 weeks after surgery). The scar is less remarkable and pigmented in the treated left eyelid in comparison with the nontreated right eyelid.

Figure 2 Eyelid appearance and scar in another representative patient.

Notes: Top row (before surgery), middle row (6 weeks after surgery), and bottom row (10 weeks after surgery). The nontreated left eyelid scar is more notable and erythematous compared with the treated right eyelid 6 weeks after surgery; however, this difference flattened in the 10th week.

Table 2 Grading of erythema in product and control groups

Grading	0	1	2	3	4	5	P-value
Week 2							0.073
Product	0	0	0	13	7	0
Control	0	0	0	15	5	0
Week 6							0.47
Product	8	5	7	0	0	0
Control	5	7	7	0	1	0
Week 10							0.56
Product	14	6	0	0	0	0
Control	12	7	1	0	0	0
Week 14							1.00
Product	18	2	0	0	0	0
Control	18	2	0	0	0	0

Table 3 Grading of pigmentation in product and control groups

	0	1–2 (mild)	3 (moderate)	4 (severe)	P-value
Week 2					1.00
Product	6	14	0	0
Control	5	15	0	0
Week 6					0.48
Product	7	13	0	0
Control	4	16	0	0
Week 10					1.00
Product	11	9	0	0
Control	10	10	0	0
Week 14					1.00
Product	19	1	0	0
Control	19	1	0	0

Table 4 Investigator assessment of the eyelid scar. The investigator selected which eyelid had a better scar appearance

	Treated eyelids	Control eyelids	The same	P-value
Week 2	3	4	13	1.00
Week 6	10	7	3	0.63
Week 10	12	2	8	0.039
Week 14	10	10	0	1.00