Ocular melanoma-when you have seen one, you have not seen them all: a clinical outcome study from the Surveillance, Epidemiology and End Results (SEER) database (1973–2012)

Figures & data

Table 1 Demographic profile of 8,165 ocular melanoma patients from the SEER database, 1973–2012

Variable	Overall OM	UM	CM	P-value
Frequency, N (%)	8,165	7,516 (92.1)	649 (7.9)
Mean age-adjusted incidence (per million)	5.5±0.1	5.1±0.1	0.4±0.0	<0.01
Age (years), N (%)
Mean age (mean ± SD)	61.4±15.3	61.4±15	61.7±18.6	0.63
Under 50	1,717 (21.0)	1,561 (20.8)	156 (24.0)	0.05
50–79	5,529 (67.7)	5,144 (68.4)	385 (59.4)	<0.01
80 and above	919 (11.3)	811 (10.8)	108 (16.6)	<0.01
Sex, N (%)
Male	4,263 (52.2)	3,933 (52.3)	330 (50.8)	0.47
Female	3,902 (47.8)	3,583 (47.7)	319 (49.2)	0.47
Ethnicity, N (%)*
Caucasian	7,540 (93.9)	7,000 (94.7)	540 (85.3)	<0.01
Hispanic	342 (4.3)	287 (3.9)	55 (8.7)	<0.01
African American	54 (0.7)	40 (0.5)	14 (2.2)	<0.01
Others (Asian, Pacific Islanders, Native Americans)	91 (1.1)	67 (0.9)	24 (3.8)	<0.01

Note:

* Data presented for patients with available data only.

Abbreviations: CM, conjunctival melanoma; N, number; OM, ocular melanoma; SD, standard deviation; SEER, Surveillance, Epidemiology, and End Results; UM, uveal melanoma.

Table 2 Tumor characteristics of 8,165 ocular melanoma patients from the SEER database, 1973–2012

	Overall OM	UM	CM	P-value
Frequency, N (%)	8,165	7,516 (92.1)	649 (7.9)
Laterality, N (%)*
Right	4,049 (50.1)	3,759 (50.5)	290 (45.5)	<0.01
Left	4,025 (49.8)	3,679 (49.4)	346 (54.3)	<0.01
Bilateral	3 (0.1)	2 (0.1)	1 (0.2)	0.08
Stage, N (%)*
Localized	6,602 (90.1)	6,126 (90.9)	476 (81.2)	<0.01
Regional	601 (8.2)	506 (7.5)	95 (16.2)	<0.01
Distant	124 (1.7)	109 (1.6)	15 (2.6)	0.09

Note:

* Data presented for patients with available data only.

Abbreviations: CM, conjunctival melanoma; N, number; OM, ocular melanoma; SEER, Surveillance, Epidemiology, and End Results; UM, uveal melanoma.

Table 3 Treatment and survival outcomes of 8,165 ocular melanoma patients from the SEER database, 1973–2012

	Overall OM	UM	CM	P-value
Frequency, N (%)	8,165	7,516 (92.1)	649 (7.9)
Treatment, N (%)*
Surgery only	3,769 (47.1)	3,218 (42.8)	565 (88.7)	<0.01
Radiation only	3,192 (39.9)	3,232 (43)	6 (0.9)	<0.01
Both	538 (6.7)	527 (7)	15 (2.4)	<0.01
Neither	504 (6.3)	539 (7.2)	51 (8.0)	0.44
Overall survival in years (mean ± SD)	14.6±0.2	14.6±0.2	15.4±0.9	<0.01
Overall mortality, N (%)	3,718 (45.5)	3,466 (46.1)	252 (38.8)	<0.01
Cancer-specific mortality, N (%)	1,756 (21.5)	1,870 (24.9)	99 (20.0)	<0.01
Cancer-specific relative survival (%)
1 year	96	96	95	0.25
2 years	89	89	88	0.43
5 years	71	70	73	0.11

Note:

* Data presented for patients with available data only.

Abbreviations: CM, conjunctival melanoma; N, number; OM, ocular melanoma; SD, standard deviation; SEER, Surveillance, Epidemiology, and End Results; UM, uveal melanoma.

Figure 1 Kaplan–Meier estimate of 10-year survival for 8,159 ocular melanoma patients from the SEER database, 1973–2012.

Abbreviations: Cum Survival, cumulative survival; SEER, Surveillance, Epidemiology, and End Results.

Figure 2 Kaplan–Meier estimate of 10-year survival for 7,516 uveal melanoma patients and 649 conjunctival melanoma patients from SEER database, 1973–2012.

Abbreviations: Cum Survival, cumulative survival; SEER, Surveillance, Epidemiology, and End Results.