Testing the clinical value of multifocal electroretinography and microperimetry and the effects of intravitreal therapy with ranibizumab on macular function in the course of wet age-related macular degeneration: a 1-year prospective study

Figures & data

Table 1 Examinations undertaken during the 12-month study period

Visit number	Baseline	2–11	6	12
Time of visit	Day 1–2	Monthly	Month 6	Month 12
Information	X
Multifocal ERG	X	X	X	X
Microperimetry	X	X	X	X
BCVA	X	X	X	X
Clinical examination	X	X	X	X
OCT	X	X	X	X
Angiography	X	X*	X*	X*

Note:

* Angiography was performed if required to further decide on first-line therapy with ranibizumab.

Abbreviations: ERG, electroretinography; BCVA, best-corrected visual acuity; OCT, optical coherence tomography.

Figure 1 Flowchart about the progress of the study population during the course of the study.

Table 2 Demographics and baseline values of the 20 patients included in the study

Demographics	n	%
Sex (female/male)	15/5	75/25
Eye (left/right)	13/7	65/35
Race (Caucasian/other)	20	100/0

Concomitant diseases and medication	No		Yes
	n	%	n	%
Hypertension	7	35	13	65
Arrhythmia	20	100	0	0
Other diseases	3	15	17	85
Anticoagulants/antiaggregants	11	55	9	45
Previous ranibizumab	3	15	17	85
Antiglaucoma	17	85	3	15
Pseudophakia	11	55	9	45

Age and baseline values	MV	SD
Age, years	75.5	6.84
IOP	14.55	2.54
mfERG P1 (nV/deg^2)	52.6	44.85
mfERG P2 (nV/deg^2)	31.15	15.11
mfERG P3 (nV/deg^2)	24.85	8.82
mfERG P4 (nV/deg^2)	19	6.37
mfERG P5 (nV/deg^2)	15.3	6.06
Visual acuity (logMAR)	0.38	0.22
OCT (μm)	283.5	100.65
Scotoma area (mm^2)	0.55	0.84

Abbreviations: MV, mean value; SD, standard deviation; IOP, intraocular pressure; mfERG, multifocal electroretinography; logMAR, logarithm of minimum angle of resolution; OCT, optical coherence tomography.

Table 3 Visual acuity, fovea thickness, mfERG P₁, and scotoma changes after 12 months

Results	Mean (SD)
	Screening, n=20	Month 12, n=18	Difference, n=18
Visual acuity (logMAR)	0.38 (0.22)	0.41 (0.29)	0.04 (0.27)
Fovea thickness (µm)	283.5 (100.65)	266.78 (106.48)	−21.5 (165.57)
mfERG P1(nV/deg^2)	52.6 (44.85)	54.32 (40.32)	1.61 (26.88)
Scotoma (mm^2)	0.55 (0.84)	0.89 (1.37)	0.33 (1.44)

Abbreviations: mfERG, multifocal electroretinography; SD, standard deviation; logMAR, logarithm of minimum angle of resolution.