The SPARC-related modular calcium binding protein 2 (SMOC2) gene polymorphism in primary glaucoma: a case-control study

Figures & data

Figure 1 Shows different genotypes of SMOC2 polymorphism.

Notes: Lane M: 100 bp DNA marker, Lane 1 and 3: homozygous (GG) wild type (97 bp, 165 bp, and 233 bp), Lane 2: heterozygous (GA) genotype (388 bp, 233 bp, 165 bp, and 97 bp), Lane 4: mutant (AA) genotype (97 bp and 388 bp).

Table 1 Allele and genotypic distribution of the SMOC2 (G>A) polymorphism in PG patients and controls

Genotype/allele	Controls (n=202) N (Frequency %)	PG (n=204) N (Frequency %)	P-value	RR	EFa/PF	Odds ratio (95% CI)
GG	95 (47.29)	76 (37.25)	0.05b	0.66	0.23	Reference
GA	90 (44.55)	119 (58.33)	<0.01b	1.74	0.24a	1.65 (1.09–2.48)
AA	17 (8.41)	09 (4.40)	0.11	0.50	0.25	0.62 (0.27–1.56)
G	280 (69.30)	271 (66.42)	0.38	0.86	0.14	1.14 (0.85–1.53)
A	124 (30.69)	137 (33.57)	0.38	1.14	0.06a

Notes:

a Data for EF;

b statistically significant using Fisher’s exact test.

Abbreviations: PG, primary glaucoma; EF, etiological fraction; PF, preventive fraction; N, number of subjects; RR, relative risk.

Table 5 Comparison of allele and genotype distribution of the SMOC2 (G>A) polymorphism between PACG patients and controls

Genotype/allele	Controls (n=202) N (Frequency %)	PACG (n=64) N (Frequency %)	P-value	RR	EFa/PF	Odds ratio (95% CI)
GG	95 (47.29)	18 (28.21)	<0.01b	0.44	0.15	Reference
GA	90 (44.55)	42 (65.62)	<0.01b	2.37	0.18a	2.46 (1.32–4.59)
AA	17 (8.41)	04 (6.25)	0.79	0.72	0.06	1.24 (0.37–4.12)
G	280 (69.30)	78 (60.93)	0.08	0.69	0.08	1.44 (0.95–2.18)
A	124 (30.69)	50 (39.06)	0.08	1.44	0.08a

Notes:

a Data for EF;

b statistically significant using Fisher’s exact test.

Abbreviations: PACG, primary angle closure glaucoma; N, number of subjects; RR, relative risk; EF, etiological fraction; PF, preventive fraction.

Table 2 Allele and genotype distribution of the SMOC2 (G>A) polymorphism in male and female primary glaucoma patients

Genotype/allele	Male (n=103) N (Frequency %)	Female (n=101) N (Frequency %)	P-value	RR	EFa/PF	Odds ratio (95% CI)
GG	41 (39.80)	36 (35.64)	0.56	0.83	0.77	Reference
GA	56 (54.36)	61 (60.39)	0.39	1.2	0.11a	1.24 (0.69–2.20)
AA	06 (5.82)	04 (3.92)	0.75	0.66	0.05	0.75 (0.19–2.90)
G	138 (67)	133 (65.84)	0.83	0.94	0.02	1.05 (0.69–1.58)
A	68 (33)	69 (34.16)	0.83	1.05	0.02a

Note:

a Data for EF.

Abbreviations: N, number of subjects; RR, relative risk; EF, etiological fraction; PF, preventive fraction.

Figure 2 Shows the frequencies of various genotypes and alleles in the controls and POAG and PACG patients.

Abbreviations: POAG, primary open angle glaucoma; PACG, primary angle closure glaucoma.

Table 3 Allele and genotype distribution of the SMOC2 (G>A) polymorphism in POAG and PACG patients

Genotype/allele	POAG (n=140) N (Frequency %)	PACG (n=64) N (Frequency %)	P-value	Odds ratio (95% CI)
GG	65 (46.42)	18 (28.21)	0.01a	Reference
GA	70 (50)	42 (65.62)	0.04a	2.16 (1.13–4.13)
AA	05 (3.5)	04 (6.25)	0.46	2.88 (0.70–11.88)
G	200 (71.42)	78 (60.93)	0.03a	1.60 (1.03–2.48)
A	80 (28.57)	50 (39.06)	0.03a

Note:

a Statistically significant using Fisher’s exact test.

Abbreviations: POAG, primary open angle glaucoma; PACG, primary angle closure glaucoma; N, number of subjects; RR, relative risk.

Table 4 Comparison of allele and genotype distribution of the SMOC2 (G>A) polymorphism between POAG patients and controls

Genotype/allele	Controls (n=202) N (Frequency %)	POAG (n=140) N (Frequency %)	P-value	RR	EFa/PF	Odds ratio (95% CI)
GG	95 (47.29)	65 (46.42)	0.99	0.97	0.01	Reference
GA	90 (44.55)	70 (50)	0.34	1.24	0.08a	1.13 (0.72–1.77)
AA	17 (8.41)	05 (3.5)	0.07	0.40	0.25	0.43 (0.15–1.22)
G	280 (69.30)	200 (71.42)	0.67	1.10	0.10a	0.90 (0.64–1.26)
A	124 (30.69)	80 (28.57)	0.67	0.90	0.03

Note:

a Data for EF.

Abbreviations: POAG, primary open angle glaucoma; N, number of subjects; RR, relative risk; EF, etiological fraction; PF, preventive fraction.