No improvement in injection frequency or in visual outcome over time in two cohorts of patients from the same Swedish county treated for wet age-related macular degeneration

Figures & data

Table 1 NEI VFQ-25 score at baseline and at follow-up in cohort 1 and cohort 2

Questions	Cohort 1 (mean ± SD)		P-value	Cohort 2 (mean ± SD)		P-value
	Baseline	End point		Baseline	End point
General health	57±26	47±24	0.004	53±26	52±20	0.805
General vision	55±22	56±23	0.512	53±22	58±17	0.172
Ocular pain	84±19	79±24	0.024	78±23	83±19	0.274
Near activities	51±23	50±28	0.932	53±29	55±28	0.716
Distance activities	57±28	46±31	0.011	57±29	57±26	0.756
Mental health	59±29	61±31	0.285	68±57	70±25	0.134
Social functioning	75±27	65±30	0.029	72±28	78±27	0.330
Role difficulties	67±29	56±32	0.034	54±36	64±34	0.149
Dependency	71±34	65±34	0.137	69±34	76±28	0.345
Color vision	82±30	66±30	0.001	79±34	73±33	0.058
Peripheral vision	62±27	58±28	0.393	64±30	63±31	1.0

Note: P<0.05 is considered significant.

Abbreviation: NEI VFQ-25, National Eye Institute Visual Functioning Questionnaire 25.

Figure 1 VA outcome was divided into three subgroups: gain of ≥15 letters (cohort 1: n=5, cohort 2: n=3), gain or loss (stabilization) of <15 letters (cohort 1: n=29, cohort 2: n=14), and loss of ≥15 letters (cohort 1: n=16, cohort 2: n=9). This figure shows the (A) mean change in overall NEI VFQ-25 composite score, and mean change in NEI VFQ-25 score of (B) near activities subscale, (C) distance activities subscale, and (D) vision-specific dependency subscale. Error bars represent the standard error of the mean.

Abbreviations: VA, visual acuity; NEI VFQ-25, National Eye Institute Visual Functioning Questionnaire 25.

Figure 2 VA outcome was divided into three subgroups in the merged cohorts: gain of ≥15 letters (n=8), gain or loss (stabilization) of <15 letters (n=43), and loss of ≥15 letters (n=25). This figure shows the (A) mean change in overall NEI VFQ-25 composite score, and mean change in NEI VFQ-25 score of (B) near activities subscale, (C) distance activities subscale, and (D) vision-specific dependency subscale. Error bars represent the standard error of the mean.

Abbreviations: VA, visual acuity; NEI VFQ-25, National Eye Institute Visual Functioning Questionnaire 25.