Photodynamic therapy combined with antivascular endothelial growth factor treatment for recalcitrant chronic central serous chorioretinopathy

Figures & data

Figure 1 (A) FA and (B) ICGA studies of patient 1 prior to treatment with combination PDT and bevacizumab demonstrating (A) late focal leakage in the papillomacular bundle as well as focal staining and a PED and (B) ICGA showing increased choroidal perfusion and probable focal PED. No definitive CNV was identified.

Abbreviations: CNV, choroidal neovascularization; FA, fluorescein angiography; ICGA, indocyanine green angiography; PDT, photodynamic therapy; PED, pigment epithelial detachment.

Table 1 Principal clinical characteristics of eight eyes of eight patients included in the report

Patient	Sex	Age (years)	Eye	Baseline BCVA logMAR	Final BCVA logMAR	Baseline OCT average macular thickness (µm)	Final OCT average macular thickness (µm)	Treatment failed prior to initiation of combination therapy	Duration of CSC prior to combination therapy (months)	Follow-up time after combination therapy (months)
1	Male	46	Left	0.09691	0.0000	457.4	317.8	Topical NSAID, focal photocoagulation ×3	11	8
2	Male	45	Left	0.09691	0.09691	376.6	316	Topical NSAID, focal photocoagulation	7	4
3	Male	70	Left	0.5440	0.09691	427	300	Intravitreal bevacizumab ×3	6	3
4	Female	53	Right	0.0000	0.0000	348	297	Topical NSAID, intravitreal bevacizumab	6	30
5	Male	35	Left	0.1760	0.0000	402.2	286.6	PDT, focal photocoagulation	12	18
6	Male	36	Left	0.0000	−0.1249	430.2	272	Topical NSAID	4	6
7	Male	41	Right	0.1760	0.0000	382.2	303.4	Topical NSAID, focal photocoagulation	6	15
8	Male	44	Right	0.1760	0.0000	366.4	306.8	Topical NSAID, focal photocoagulation	8	25

Abbreviations: BCVA, best-corrected visual acuity; CSC, central serous chorioretinopathy; NSAID, nonsteroidal anti-inflammatory drug; OCT, optical coherence tomography; PDT, photodynamic therapy.

Figure 2 OCT studies and macular thickness of patient 7.

Notes: (A) Exudative detachment at the time of presentation. (B) Increasing detachment 1 month after topical bromfenac 0.07% and (C) 1 month after focal laser. Resolution (D) 3 months and (E) 15 months after combination PDT and intravitreal bevacizumab.
Abbreviations: OCT, optical coherence tomography; PDT, photodynamic therapy.