Investigating the potential benefits of a new artificial tear formulation combining two polymers

Figures & data

Figure 1 Structure of CMC and HA.

Notes: (A) In solution, CMC forms a relatively short linear polymer (n~400); (B) compared with CMC, HA is a much longer polymer (n>5,000) that forms a random, globular coil in solution, rather than being linear.
Abbreviations: CMC, carboxymethylcellulose; HA, hyaluronic acid.

Figure 2 Rheological analysis of combinations of low (A), medium (B), and high (C) concentrations of CMC and HA polymers.

Notes: Data points represent mean ± standard deviation. Viscosity and shear rate are presented on a log scale.
Abbreviations: CMC, carboxymethylcellulose; HA, hyaluronic acid.

Figure 3 Bulk viscosity of the combined solution of 0.5% CMC and 0.1% HA was higher than predicted by additive effects.

Note: Data represent mean ± standard deviation Brookfield viscosity at 60 rpm (approximately equivalent to 79.2/second).
Abbreviations: CMC, carboxymethylcellulose; HA, hyaluronic acid.