Advanced search
Publication Cover
Clinical Ophthalmology Volume 11, 2017 - Issue
Submit an article Journal homepage
78
Views
7
CrossRef citations to date
0
Altmetric
Original Research

Single nucleotide polymorphism 1623 A/G (rs180195) in the promoter of the Thyroglobulin gene is associated with autoimmune thyroid disease but not with thyroid ophthalmopathy

Hooshang Lahooti1 Thyroid Research Laboratory, Sydney Medical School – Nepean Clinical School, The University of Sydney, Kingswood, NSW, Australia;2 Nepean Blue Mountains Local Health District, Kingswood, NSW, AustraliaCorrespondence[email protected]
,
Senarath Edirimanne1 Thyroid Research Laboratory, Sydney Medical School – Nepean Clinical School, The University of Sydney, Kingswood, NSW, Australia;2 Nepean Blue Mountains Local Health District, Kingswood, NSW, Australia
,
John P Walsh3 Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia;4 School of Medicine and Pharmacology, The University of Western Australia, Crawley, WA, Australia
,
Leigh Delbridge5 Department of Surgery, Royal North Shore Hospital, St Leonards, NSW, Australia;6 Sydney Medical School – Northern Clinical School, The University of Sydney, NSW, Australia
,
Emily J Hibbert1 Thyroid Research Laboratory, Sydney Medical School – Nepean Clinical School, The University of Sydney, Kingswood, NSW, Australia;2 Nepean Blue Mountains Local Health District, Kingswood, NSW, Australia
&
Jack R Wall1 Thyroid Research Laboratory, Sydney Medical School – Nepean Clinical School, The University of Sydney, Kingswood, NSW, Australia;2 Nepean Blue Mountains Local Health District, Kingswood, NSW, Australia
Pages 1337-1345 | Published online: 25 Jul 2017

Figures & data

Table 1 Demographics, clinical details of patients with thyroid autoimmunity and control subjects without autoimmune disease

Table 2 Characteristics of rs180195 informative polymorphism identified in TG gene

Table 3 Genotype of TG rs180195 SNP distribution in patients with autoimmune thyroid disease with and without ophthalmopathy and controls

Table 4 Major and minor allele distribution of TG rs180195 SNP in patients with autoimmune thyroid disease with and without ophthalmopathy and controls

Table 5 Wild-type genotype of TG rs180195 SNP distribution in patients with autoimmune thyroid disease with and without ophthalmopathy, and controls

Table 6 Heterozygous genotype of TG rs180195 SNP distribution in patients with autoimmune thyroid disease with and without ophthalmopathy, and controls

Table 7 Homozygous genotype of TG rs180195 SNP distribution in patients with autoimmune thyroid disease with and without ophthalmopathy, and controls

Figure 1 The levels of TSH, TPO AB, FT4, TG AB, and age measured in wild-type (GG), heterozygote (GA) and rare homozygote (AA) genotypes.

Notes: (A–E)rs180195 polymorphism in promoter of TG gene conceivably, regulates transcription activity of TG gene and possibly translation of TG protein – this effect can be manifested in levels of TSH, TPO, T4, TG, and age at the onset of disease. As reflection of function of TG, we measured levels of each of these parameters in wild-type, heterozygote, and rare homozygote genotypes. *Significant difference in TSH levels was observed between the wild-type and heterozygote genotype (A).
Abbreviations: AB, antibody; TSH, thyroid stimulating hormone; T4, tetraiodothyronine; FT4, free tetraiodothyronine.
Figure 1 The levels of TSH, TPO AB, FT4, TG AB, and age measured in wild-type (GG), heterozygote (GA) and rare homozygote (AA) genotypes.

Table 8 Assessments of correlation between levels of TG protein and other biochemical parameters affected by TG protein in wild-type GG and heterozygote GA genotypes of HT patients

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.