Diurnal IOP-lowering efficacy and safety of travoprost 0.004% compared with tafluprost 0.0015% in patients with primary open-angle glaucoma or ocular hypertension

Figures & data

Table 1 Patient demographics of the safety population

Demographic	Total N = 51
Gender (%)
Male	39.2
Female	60.8
Age (mean ± SD, years)	68.8 ± 9.0
Race (%)
Caucasian	100

Abbreviation: SD, standard deviation.

Figure 1 Decrease in diurnal IOP from baseline produced by travoprost and tafluprost. (intent-to-treat population, N = 48).

Note: *Travoprost showed a significantly larger decrease in IOP from baseline than tafluprost (P < 0.05).
Abbreviation: IOP, intraocular pressure.

Table 2 Mean intraocular pressure at baseline and after six weeks of therapy with travoprost and tafluprost (intent-to-treat population, N = 48)

Hour	Baseline IOP (mean ± SD)	Travoprost IOP (mean ± SD)	Tafluprost IOP (mean ± SD)	Pvalue
8 AM	25.9 ± 2.45	17.0 ± 2.36	17.5 ± 2.20	0.06
10 AM	25.0 ± 3.08	16.7 ± 2.39	17.3 ± 2.50	0.02a
12 PM	24.3 ± 3.47	16.7 ± 2.47	17.2 ± 2.46	0.01a
2 PM	23.9 ± 3.22	16.9 ± 2.69	17.3 ± 2.77	0.09
4 PM	24.1 ± 3.06	17.1 ± 2.85	17.6 ± 2.80	0.01a
6 PM	24.1 ± 2.90	16.9 ± 3.12	17.6 ± 3.13	<0.01a
8 PM	24.3 ± 3.35	17.1 ± 3.17	17.7 ± 3.23	0.01a
12-hour mean	24.5 ± 2.89	16.9 ± 2.59	17.5 ± 2.62	0.01a

Note:

a Bolded P values represent statistical significance.

Abbreviations: IOP, intraocular pressure; SD, standard deviation.

Table 3 Mean change from baseline on the symptom survey scores (based on a scale of 0–4) after six weeks of therapy with travoprost and tafluprost (intent-to-treat population, N = 48)

Question	Travoprost (mean ± SD)	Pvalue	Tafluprost (mean ± SD)	Pvalue
Do you experience pain in or around your eyes when exposed to light?	0.02 ± 0.25	0.57	0.06 ± 0.24	0.08
Do you experience blurred or dim vision?	−0.02 ± 0.33	0.66	−0.02 ± 0.33	0.66
Do you experience stinging or burning?	0.02 ± 0.44	0.74	0.04 ± 0.50	0.57
Do you feel that something is in your eyes or under your lids?	0.04 ± 0.29	0.32	0.06 ± 0.24	0.08
Do you experience deep pain in or around your eyes?	0.00 ± 0.21	1.00	0.00 ± 0.21	1.00
Have you noticed redness in your eyes?	0.17 ± 0.21	0.01a	0.27 ± 0.49	<0.01a

Note:

a Bolded P values represent statistical significance.

Abbreviation: SD, standard deviation.