Alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians

Figures & data

Figure 1 Schematic illustration of 3.45 mm diameter grid and chosen retinal layers for segmentation.

Abbreviatons: RNFL, retinal nerve fiber layer; GCLIPL, ganglion cell/inner plexiform layer; INL, inner nuclear layer; OPLONL, outer plexiform layer/outer nuclear layer; PR, photoreceptor complex.

Table 1 Demographics, mean ± SD of each evaluated layer for each age-group

	60–69 years	70–79 years	80–89 years	≥90 years
N (patients)	40	40	40	40
Age, years (mean ± SD)	64.95±3.02	75.40±3.04	83.33±2.64	93.40±2.79
Gender
Female (n)	20	20	20	12
Male (n)	20	20	20	28
Retinal layers
RNFL, μm (mean ± SD)	21.80±2.18	22.62±2.25	22.18±2.23	22.82±2.97
GCLIPL, μm (mean ± SD)	83.35±7.35	78.54±6.67	74.52±9.67	74.38±9.09
INL, μm (mean ± SD)	37.23±3.02	36.72±4.24	36.43±3.54	36.01±3.24
OPLONL, μm (mean ± SD)	104.95±6.56	103.66±6.94	105.04±7.95	104.23±7.59
PR, μm (mean ± SD)	83.03±3.31	81.45±2.89	81.24±3.59	79.34±2.09
RT, μm (mean ± SD)	330.64±12.63	323.19±13.71	321.22±14.69	316.83±18.35

Abbreviations: GCLIPL, ganglion cell/inner plexiform layer; INL, inner nuclear layer; OPLONL, outer plexiform-outer nuclear layer; PR, photoreceptor complex; RNFL, retinal nerve fiber layer; RT, retinal thickness; SD, standard deviation.

Figure 2 Regression equations for age-related retinal thickness changes in subjects aged 60–100 years.

Abbreviaton: GCLIPL, ganglion cell layer/inner plexiform layer.

Note: GCLIPL, photoreceptor layer and retinal thickness showed significant age-related decrease (P<0.001).