Evaluating intraocular pressure-lowering solutions for the treatment of open-angle glaucoma: comparison between bimatoprost 0.03% and bimatoprost 0.01% — an observational switch study

Figures & data

Table 1 Baseline characteristics of patients

	Switched group, n=30	Nonswitched group, n=35
Age (years)
Mean (range)	71 (48–93)	69 (45–94)
Sex, n (%)
Male	9 (29)	12 (34)
Female	21 (70)	23 (66)
Race, n (%)
African American	21 (70)	27 (77)
White	8 (26)	8 (23)
Hispanic	1 (3)	0
IOP-lowering Rx, n (%)
Bimatoprost alone	18 OD (67); 19 OS (63)	10 OD (29); 10 OS (29)
Bimatoprost +1 adjunctive Rx	4 OD (14); 5 OS (16)	6 OD (17); 7 OS (21)
Bimatoprost +2 adjunctive Rx	4 OD (14); 4 OS (13)	11 OD (31); 10 OS (29)
Bimatoprost +3 adjunctive Rx	1 OD (4); 2 OS (6)	8 OD (23); 7 OS (21)
Baseline IOP (mean ± SD)
Right eye	16.96±5.03 mmHg	17.40±4.61 mmHg
Left eye	17.67±5.33 mmHg	17.63±3.97 mmHg

Abbreviations: IOP, intraocular pressure; OD, right eye; OS, left eye.

Figure 1 Mean IOP changes comparing bimatoprost 0.01% solution to bimatoprost 0.03% solution before and after switch along with nonswitch patients.

Abbreviations: IOP, intraocular pressure; OD, right eye; OS, left eye.

Table 2 Mean and range of IOP for switch and nonswitch groups at various time points

	Time point (months)
	−6	−3	0	3	6	12
Switch OD
Mean ± SD (mmHg)	17.75±5.07	17.18±5.28	16.96±5.03	16.29±4.60	16.92±5.00	17.60±4.34
IOP range mmHg	9–32	10–32	11–31	9–27	8–27	11–26
Switch OS (mmHg)
Mean ± SD	17.39±4.95	17.35±4.67	17.67±5.33	16.51±4.27	15.89±4.37	17.00±3.37
IOP range mmHg	10–32	10–32	11–36	11–27	10–27	12–24
Nonswitch OD (mmHg)
Mean ± SD	17.14±3.48	17.49±0.615	17.40±4.61	18.32±4.90	18.22±5.25	17.0±4.43
IOP range mmHg	11–26	11–27	8–31	9–29	10–38	9–26
Nonswitch OS (mmHg)
Mean ± SD	17.25±3.59	17.78±3.20	17.63±3.97	18.37±5.99	17.80±5.58	16.88±5.92
IOP range mmHg	12–28	11–24	9–31	10–44	12–36	10–44

Abbreviations: IOP, intraocular pressure; OD, right eye; OS, left eye.

Table 3 Differences between mean IOP at a given time point and time of switch (at 0 months)

	Time point (months)
	−6	−3	0	3	6	12
Switch OD	0.83	0.19	Baselin	−0.63	−0.14	0.51
Switch OS	−0.1	−0.23	Baselin	−1	−1.72	−0.6
Nonswitch OD	−0.26	0.09	Baselin	0.92	0.82	−0.4
Nonswitch OS	−0.38	0.15	Baseline	0.74	0.17	−0.75

Abbreviations: IOP, intraocular pressure; OD, right eye; OS, left eye.