Changes of outer retinal microstructures after photodynamic therapy for chronic central serous chorioretinopathy

Figures & data

Figure 1 Thick arrow in the fundus image refers to the same place where thin arrow points to the spectral domain optical coherence tomography scan.

Figure 2 A representative case with chronic CSC.

Notes: A 60-year-old woman received half-fluence PDT and was followed for 6 months. Right columns show reflectivity profile which was calculated from spectral-domain optical coherence tomography images on the left side. A horizontal axis shows reflectivity, and the second and last distinct peaks represent the EZ line and RPE, respectively. Photoreceptor outer segment length was calculated from the distance between EZ and RPE. White arrows indicate the measurement points. Measurements were performed within the irradiated area but there was no existence of subnucleus reticularis dorsalis, and at the same points throughout the study.
Abbreviations: CSC, central serous chorioretinopathy; EZ, ellipsoid zone; M, months; PDT, photodynamic therapy; RPE, retinal pigment epithelium.

Figure 3 Serial changes in mean central IFT after half-fluence PDT in chronic central serous chorioretinopathy.

Notes: The mean IFT at 1, 3 and 6 months after PDT was not significantly different from that before (P=0.30*, 0.22**, and 0.22***, respectively, paired t-test). Bars show standard errors of the means.
Abbreviations: IFT, inner foveal thickness; M, months; PDT, photodynamic therapy.

Figure 4 Serial changes in mean PROS length of the irradiated area after half-fluence PDT in chronic central serous chorioretinopathy.

Notes: The mean PROS length at 1 month was less than that before PDT (P=0.020*, paired t-test); however, at 3 and 6 months, there was no significant difference compared with that before PDT (P=0.52, 1.00, respectively, paired t-test). Bars show standard errors of the means.
Abbreviations: M, months; PDT, photodynamic therapy; PROS, photoreceptor outer segment.

Figure 5 Serial changes in mean PROS length of nonirradiated area after half-fluence PDT in chronic central serous chorioretinopathy.

Notes: The mean PROS length of the nonirradiated area at 1, 3 and 6 months after PDT did not significantly differ from that before (P=0.66*, 0.90**, and 0.60***, respectively, paired t-test). Bars show standard errors of the means.
Abbreviations: M, months; PDT, photodynamic therapy; PROS, photoreceptor outer segment.

Table 1 Repeatability for inner foveal thickness, PROS length and choroidal thickness in CSC obtained using SD-OCT (n=21)

	Intraclass correlation coefficient (95% CI)
	Intraclass repeatability	Interclass repeatability
Inner foveal thickness	0.99 (0.98, 0.99)	0.99 (0.99, 0.99)
PROS length	0.92 (0.82, 0.96)	0.90 (0.78, 0.96)
Choroidal thickness	0.72 (0.44, 0.88)	0.83 (0.58, 0.93)

Abbreviations: CSC, central serous chorioretinopathy; PROS, photoreceptor outer segment; SD-OCT, spectral-domain optical coherence tomography.

Table 2 Changes in inner foveal thickness after PDT (n=21)

	Mean inner foveal thickness ± SD (μm)
	Pre-PDT	1 month post-PDT	3 months post-PDT	6 months post-PDT
	87.3±36.6	91.0±40.6	92.4±42.3	93.0±42.5
P-valuea		0.30	0.22	0.22

Note:

a Paired t-test (compared with pre-PDT).

Abbreviation: PDT, photodynamic therapy.

Table 3 Changes in PROS length after PDT (n=21)

	Mean PROS length ± SD (μm)
	Pre-PDT	1 month post-PDT	3 months post-PDT	6 months post-PDT
Irradiated area	43.5±5.7	40.4±7.5	43.0±5.4	43.5±4.3
P-valuea		0.020	0.53	1.00
Nonirradiated area	41.8±6.4	41.4±5.3	42.0±4.7	42.3±4.3
P-valuea		0.66	0.90	0.60

Note:

a Paired t-test (compared with pre-PDT).

Abbreviations: PDT, photodynamic therapy; PROS, photoreceptor outer segment.

Table 4 Changes in PROS length after PDT in irradiated area in half-fluence and half-dose groups

	Mean PROS length ± SD (μm)
	Pre-PDT	1 month post-PDT	3 months post-PDT	6 months post-PDT
Half-fluence group (n=15)	42.8±6.0	38.9±8.0	42.8±5.2	43.6±4.2
P-valuea		0.033	1.00	0.44
Half-dose group (n=6)	45.3±4.8	44.3±4.8	43.3±6.4	43.3±5.1
P-valuea		0.20	0.11	0.23

Note:

a Paired t-test (compared with pre-PDT).

Abbreviations: PDT, photodynamic therapy; PROS, photoreceptor outer segment.

Table 5 Changes in choroidal thickness after PDT (n=21)

	Mean choroidal thickness ± SD (μm)
	Pre-PDT	1 month post-PDT	3 months post-PDT	6 months post-PDT
Irradiated area
Fovea	403±135	358±139a	332±122a	325±117a
Extrafoveal	382±114	340±117a	320±112a	321±113a
Nonirradiated area	297±126	260±110a	264±110a	259±109a

Note:

a P<0.001 (paired t-test, compared with pre-PDT).

Abbreviation: PDT, photodynamic therapy.