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Clinical Ophthalmology Volume 11, 2017 - Issue
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Original Research

Integrated results from the COPERNICUS and GALILEO studies

Amelie Pielen1 Eye Center, University Hospital Freiburg, Eye Hospital, Freiburg;2 Hannover Medical School, University Eye Hospital, Hannover, GermanyCorrespondence[email protected]
,
W Lloyd Clark3 Palmetto Retina Center, Columbia, SC, USA
,
David S Boyer4 Retina-Vitreous Associates Medical Group, Beverly Hills, CA, USA
,
Yuichiro Ogura5 Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
,
Frank G Holz6 Department of Ophthalmology, University of Bonn, Bonn, Germany
,
Jean-Francois Korobelnik7 Service d’ophtalmologie, CHU de Bordeaux;8 Service d’ophtalmologie, University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Team LEHA, UMR 1219, Bordeaux, France
,
Brigitte Stemper9 Bayer AG, Berlin;10 Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany
,
Friedrich Asmus9 Bayer AG, Berlin
,
Kay D Rittenhouse11 Bayer US LLC, Whippany, NJ
,
Christiane Ahlers9 Bayer AG, Berlin
,
Robert Vitti12 Regeneron Pharmaceuticals, Tarrytown, NY, USA
,
Namrata Saroj12 Regeneron Pharmaceuticals, Tarrytown, NY, USA
,
Oliver Zeitz9 Bayer AG, Berlin;13 AKH Eye Clinic, Braunschweig;14 Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Augenheilkunde, Hamburg, Germany
&
Julia A Haller15 Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA
 show all
Pages 1533-1540 | Published online: 23 Aug 2017

Figures & data

Table 1 Treatment groups

Table 2 Baseline demographic and disease characteristics (full analysis set)

Figure 1 Mean change in BCVA for (A) COPERNICUS and GALILEO and (B) integrated data set from baseline to week 24 (LOCF).

Abbreviations: BCVA, best-corrected visual acuity; ETDRS, Early Treatment Diabetic Retinopathy Study; LOCF, last observation carried forward.
Figure 1 Mean change in BCVA for (A) COPERNICUS and GALILEO and (B) integrated data set from baseline to week 24 (LOCF).

Figure 2 Mean change in BCVA from baseline to week 24–week 52 (LOCF).

Abbreviations: BCVA, best-corrected visual acuity; ETDRS, Early Treatment Diabetic Retinopathy Study; LOCF, last observation carried forward.
Figure 2 Mean change in BCVA from baseline to week 24–week 52 (LOCF).

Figure 3 Mean change in CRT for (A) COPERNICUS and GALILEO and (B) integrated data set from baseline to week 24 (LOCF).

Abbreviations: CRT, central retinal thickness; LOCF, last observation carried forward.
Figure 3 Mean change in CRT for (A) COPERNICUS and GALILEO and (B) integrated data set from baseline to week 24 (LOCF).

Figure 4 Mean change in CRT from baseline to week 24–week 52 (LOCF).

Abbreviations: CRT, central retinal thickness; LOCF, last observation carried forward.
Figure 4 Mean change in CRT from baseline to week 24–week 52 (LOCF).

Table 3 Ocular SAEs from baseline to week 52 by MedDRA Preferred Term (safety analysis set)

Table 4 APTC-ATEs from baseline to week 52 (safety analysis set)

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