Intravitreal bevacizumab injections versus dexamethasone implant for treatment-naïve retinal vein occlusion related macular edema

Figures & data

Table 1 Baseline variables according to primary treatment for RVO-related CME

Variables	IVB (n=121)	DEX implant (n=14)	p-value
Gender (M/F)	57:64	8:6	0.477
Age (years)	72.8±1.06 (45–94)	72.1±3.88 (47–92)	0.849
RVO (branch:central)	73:48	10:4	0.565
BCVA (logMAR)	0.76±0.06 (0–2.3)	0.58±0.12 (0–1.3)	0.814
CRT (μm)	543.9±19.8 (217–1,138)	555.4±39.5 (322–774)	0.797
Lens status (phakic:IOL)	87:34	10:4	1.000
Glaucoma medication (n/%)	15 (12%)	2 (14%)	0.690
IOP (mmHg)	15.6±0.4 (6–30)	16.1±1.1 (10–23)	0.650
IOP ≥22 mmHg (n/%)	11 (9%)	1 (7%)	1.000
IOP ≥26 mmHg (n/%)	2 (2%)	0 (0%)	1.000

Notes: Data are given as mean (±SEM) and range or absolute number. For two-group comparisons, qualitative data was analyzed by two-factor χ² test (or with the Fisher’s exact test when values in any of the cells of a contingency table were below five) and continuous variables by Student’s t-test.

Abbreviations: BCVA, best-corrected visual acuity; CRT, central retinal thickness; CME, cystic macular edema; DEX, dexamethasone; IOL, intraocular lens; IOP, intraocular pressure; IVB, intravitreal bevacizumab; RVO, retinal vein occlusion; SEM, standard error of the mean; MAR, minimum angle of resolution.

Figure 1 Three-month BCVA gain of the treatment-naïve CME eyes secondary to retinal vein occlusion.

Notes: Patients were given either a) intravitreal bevacizumab (IVB) as three monthly injections with the final follow-up at month 3 or b) single DEX intravitreal implant with follow-ups at months 1 and 3. BCVA was recorded before injections/implantation and at months 1 and 3; IVB (n=121), DEX implant (n=14).
Abbreviations: BCVA, best-corrected visual acuity; CME, cystoid macular edema; MAR, minimum angle of resolution; DEX, dexamethasone.

Figure 2 Three-month CRT decrease of the treatment-naïve CME eyes secondary to retinal vein occlusion.

Notes: Patients were given either a) intravitreal bevacizumab (IVB) as three monthly injections with the final follow-up at month 3 or b) single DEX intravitreal implant with follow-ups at months 1 and 3. CRT was recorded before injections/implantation and at months 1 and 3; IVB (n=121), DEX implant (n=14), *p<0.05.
Abbreviations: CRT, central retinal thickness; CME, cystoid macular edema; DEX, dexamethasone.

Figure 3 Three-month IOP change of the treatment-naïve CME eyes secondary to retinal vein occlusion.

Notes: Patients were given either a) intravitreal bevacizumab (IVB) as three monthly injections with the final follow-up at month 3 or b) single DEX intravitreal implant with follow-ups at months 1 and 3. IOP was recorded before injections/implantation and at months 1 and 3; IVB (n=121), DEX implant (n=14); **p<0.01.
Abbreviations: IOP, intraocular pressure; CME, cystoid macular edema; DEX, dexamethasone.