Diabetic corneal neuropathy: clinical perspectives

Figures & data

Table 1 Advances in the treatment of diabetic corneal disease

Therapy	Administration	References
Glutazumab (long-acting GLP-1/anti-GLP-1R antibody fusion protein)	Systematic	Li et al^Citation42
Beta-carotene	Systematic	Abdul-Hamid and Moustafa^Citation43
Resolvin-D1	Systematic	Shevalye et al^Citation44
Combination therapy of menhaden oil, α-lipoic acid, and enalapril	Systematic	Davidson et al^Citation45
Gene therapy of limbal cells		Saghizadeh et al^Citation51
Stem cell therapy		Di et al^Citation40
Substance P	Eye drops	Yang et al^Citation67
Insulin	Eye drops	Fai et al^Citation65
Thymosin beta-4	Eye drops	Sosne et al^Citation66
PEDF in combination with DHA		He et al^Citation70
CNTF	Subconjunctival injection	Zhou et al^Citation74
NGF	Eye drops	Park et al^Citation59
Nanomicelle curcumin	Intranasal administration	Guo et al^Citation71
Semaphorins	Injection to intrastromal micropocket	Zhang et al^Citation61
Extract of aloe vera	Eye drops	Atiba et al^Citation72
Epalrestat, in silicon hydrogel contact lenses	Silicon hydrogel contact lenses	Alvarez-Rivera et al^Citation63
HA	Eye drops	Di et al^Citation68
Fibronectin-derived peptide PHSRN	Eye drops	Morishige et al^Citation69

Abbreviations: GLP-1, glucagon-like peptide-1; PEDF, pigment epithelium-derived factor; DHA, docosahexaenoic acid; CNTF, ciliary neurotrophic factor; NGF, nerve growth factor; HA, sodium hyaluronate.

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Abdul-HamidMMoustafaNAmelioration of alloxan-induced diabetic keratopathy by beta-caroteneExp Toxicol Pathol2014661495924129090

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ShevalyeHYorekMSCoppeyLJEffect of enriching the diet with menhaden oil or daily treatment with resolvin D1 on neuropathy in a mouse model of type 2 diabetesJ Neurophysiol2015114119920825925322

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SaghizadehMDibCMBrunkenWJLjubimovAVNormalization of wound healing and stem cell marker patterns in organ-cultured human diabetic corneas by gene therapy of limbal cellsExp Eye Res2014129667325446319

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DiGDuXQiXMesenchymal stem cells promote diabetic corneal epithelial wound healing through TSG-6–dependent stem cell activation and macrophage switchInvest Ophthalmol Vis Sci201758104344435428810264

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FaiSAhemAMustaphaMMohd NohUKBastionMCRandomized controlled trial of topical insulin for healing corneal epithelial defects induced during vitreoretinal surgery in diabeticsAsia Pac J Ophthalmol (Phila)20176541842428828764

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SosneGRimmerDKleinmanHKOuslerGThymosin beta 4: a potential novel therapy for neurotrophic keratopathy, dry eye, and ocular surface diseasesVitam Horm201610227730627450739

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HeJPhamTLKakazuABazanHEPRecovery of corneal sensitivity and increase in nerve density and wound healing in diabetic mice after PEDF plus DHA treatmentDiabetes20176692511252028592408

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ZhouQChenPDiGCiliary Neurotrophic Factor Promotes the Activation of Corneal Epithelial Stem/Progenitor Cells and Accelerates Corneal Epithelial Wound HealingStem Cells2015331566157625546438

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ParkJHKangSSKimJYTchahHNerve growth factor attenuates apoptosis and inflammation in the diabetic corneaInvest Ophthalmol Vis Sci201657156767677527978558

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GuoCLiMQiXIntranasal delivery of nanomicelle curcumin promotes corneal epithelial wound healing in streptozotocin-induced diabetic miceSci Rep201662975327405815

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ZhangMZhouQLuoYNguyenTRosenblattMIGuaiquilVHSemaphorin3A induces nerve regeneration in the adult cornea – a switch from its repulsive role in developmentPLoS One2018131e019196229370308

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AtibaAWasfyTAbdoWGhoneimAKamalTShukryMAloe vera gel facilitates re-epithelialization of corneal alkali burn in normal and diabetic ratsClin Ophthalmol201592019202626604672

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Alvarez-RiveraFConcheiroAAlvarez-LorenzoCEpalrestat-loaded silicone hydrogels as contact lenses to address diabetic-eye complicationsEur J Pharm Biopharm201812212613629079419

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DiGQiXZhaoXZhangSZhouQEfficacy of sodium hyaluronate in murine diabetic ocular surface diseasesCornea20173691133113828644234

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MorishigeNUemuraAMoritaYNishidaTPromotion of corneal epithelial wound healing in diabetic rats by the fibronectin-derived peptide PHSRNCornea201736121544154828834817

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