Clinical and virological analysis of epidemic keratoconjunctivitis caused by adenovirus type 54 in a regional ophthalmic clinic in Kyushu, Japan

Figures & data

Table 1 Demographic features of cases of epidemic keratoconjunctivitis due to adenovirus type 54

		Range
Sex
Men	23 (42%)
Women	32 (58%)
Age (mean ± SD)	21.7±22.7	0–68
Day of first visit after onset (mean ± SD)	1.69±1.52	0–6
No. of HAdV copies (log copies/mL; mean ± SEM)	8.50±0.93	5.0–10.1

Abbreviations: HAdV, human adenovirus; SD, standard deviation; SEM, standard error of the mean.

Table 2 Relationship between clinical score and patient groups

Classification (number of cases)	Clinical score (mean ± SD)	Statistical significance
Days after onset
≤2 (42)	2.52±0.59	NS
3≤ (13)	2.38±0.49
Sex
Men (23)	2.61±2.41	NS
Women (32)	28.9±0.61
HAdV DNA number on logarithmic scale
≤8.6 (29)	2.41±0.56	NS
>8.6 (26)	2.58±0.57
Age (years)
<23 (32)	2.69±0.53	P<0.01
≥23 (23)	2.22±0.51

Abbreviations: HAdV, human adenovirus; NS, not significant.

Figure 1 Correlation between AdV DNA copies on logarithmic scale and day of sample collection after onset. Correlation coefficient was −0.237, but this correlation was not significant. DNA copies of adenovirus in log are represented in Y-axis.

Abbreviation: AdV, adenovirus.

Figure 2 Correlation between AdV DNA copies on logarithmic scale and clinical score. Correlation coefficient was 0.280 and a significant correlation was observed (P<0.05). DNA copies of adenovirus in log are represented in Y-axis.

Abbreviation: AdV, adenovirus.

Figure 3 Conjunctival finding of case of AdV type 54. Moderate follicular conjunctivitis with eye discharge of a 32-year-old man is shown.

Abbreviation: AdV, adenovirus.

Table 3 Reports of clinical characteristics of adenoviral keratoconjunctivitis in past studies and present study

Clinical findings	Incidence (%)	Study	Adenovirus species and type
Conjunctival pseudomembrane	37	Tullo and Higgins^Citation16	D10 and D19^*
	17	Darougar et al^Citation19	B7
	38		D8
	0	Uemura (present study)	D54
Keratitis	68	Tullo and Higgins^Citation16	D10 and D19^*
	56	Aoki et al^Citation18	B3
	9.1		E4
	27		D8
	61		D19^*
	70	Darougar et al^Citation19	B3
	75		E4
	100		C5
	83		B7
	95		D8
	100		B11
	50		D15 and D15/29
	1.8	Uemura (present study)	D54
Preauricular lymphadenopathy	37	Tullo and Higgins^Citation16	D10 and D19^*
	20	Aoki et al^Citation18	B3
	34		E4
	44		D8
	64		D19^*
	24	Aoki et al^Citation14	B3, E4, D19a^#, D53 and D54
	49	Uemura (present study)	D54
Multiple subepithelial corneal infiltrates	58	Tullo and Higgins^Citation16	D10 and D19^*
	25	Darougar et al^Citation19	B3
	25		E4
	100		C5
	17		B7
	95		D8
	53	Akiyoshi et al^Citation11	D54
	43	Aoki et al^Citation14	B3, E4, D19a^#, D53 and D54
	77	Uemura (present study)	D54

Notes: HAdV-19 (D19)^* has been renamed as HAdV-64 (D64). This is almost identical to HAdV-D19a^#, which is a genotype of HAdV-19 causing keratoconjunctivitis.

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