Retrobulbar hemodynamics and aqueous humor levels of endothelin-1 in exfoliation syndrome and exfoliation glaucoma

Figures & data

Table 1 ET-1 levels (in pg/mL) and retrobulbar hemodynamics results (in cm/s) for the control, XFG, and XFS groups

Parameters	Control (1) n=24	XFG (2) n=22	XFS (3) n=23	Multiple regression analysis outcomes
	Mean±SD	Mean±SD	Mean±SD	P-value	Bonferroni-adjusted pairwise comparison
ET-1*	8.44±2.6	15.93±2.8	8.92±2.7	<0.001	(1)–(2) <0.001 (1)–(3)=1.00 (2)–(3) <0.001
OA-PSV*	36.31±2.1	28.14±2.4	29.0±3.9	<0.001	(1)–(2) <0.001 (1)–(3) <0.001 (2)–(3)=0.967
OA-EDV**	8.04±1.2	7.60±2.2	8.11±1.9	0.605
OA-RI*	0.77±0.03	0.73±0.08	0.72±0.04	0.002	(1)–(2)=0.012 (1)–(3)=0.003 (2)–(3)=1.00
CRA-PSV*	11.46±1.0	9.4±0.8	8.32±0.9	<0.001	(1)–(2) <0.001 (1)–(3) <0.001 (2)–(3)=0.001
CRA-EDV*	4.57±0.7	3.74±0.5	3.14±0.5	<0.001	(1)–(2) <0.001 (1)–(3) <0.001 (2)–(3)=0.003
CRA-RI**	0.59±0.1	0.60±0.0	0.62±0.1	0.253
PCA-PSV***	10.27±0.8	10.39±0.8	9.93±1.5	0.291
PCA-EDV**	3.85±0.6	4.03±0.9	3.68±1.0	0.452
PCA-RI**	0.62±0.1	0.62±0.1	0.63±0.1	0.804

Notes:

* No statistically significant influence of age or sex.

** No statistically significant influence of group, age, or sex.

*** Statistically significant influence of sex (explained in text).

Abbreviations: CRA, central retinal artery; EDV, end diastolic velocity; ET-1, endothelin-1; OA, ophthalmic artery; PCA, posterior ciliary artery; PSV, peak systolic velocity; RI, resistivity index; XFG, exfoliation glaucoma; XFS, exfoliation syndrome.

Table 2 Pearson correlation coefficients (r) between levels of ET-1 and the hemodynamic parameters that were influenced by group

Group	OA-PSV	OA-RI	CRA-PSV	CRA-EDV
Control (n=24)
r	−0.030	0.350	−0.089	−0.049
P-value	0.888	0.093	0.680	0.822
XFG (n=22)
r	−0.262	0.430	−0.067	−0.513
P-value	0.239	0.046	0.768	0.015
XFS (n=23)
r	−0.502	0.635	−0.505	−0.511
P-value	0.015	0.001	0.014	0.013

Note: Bold values indicate statistically significant (p<0.05) results.

Abbreviations: CRA-EDV, central retina artery-end diastolic velocity; CRA-PSV, central retina artery-peak systolic velocity; ET-1, endothelin-1; OA-PSV, ophthalmic artery-peak systolic velocity; OA-RI, ophthalmic artery-resistivity index; XFG, exfoliation glaucoma; XFS, exfoliation syndrome.