Foveal threshold and photoreceptor integrity for prediction of visual acuity after intravitreal aflibercept on age-related macular degeneration

Figures & data

Figure 1 Assessment of optical coherence tomography images of patients with age-related macular degeneration treated with intravitreal aflibercept.

Note: We evaluated the presence of ELM and EZ at fovea.
Abbreviations: ELM, external limiting membrane; EZ, ellipsoid zone.

Figure 2 Results of assessments of functional and morphologic parameters of eyes with neovascular age-related macular degeneration treated with IVA injections over a 12-month period.

Notes: Assessments were made before the IVA and 3, 6, 9, and 12 months after the IVA. (A) Best-corrected visual acuity (logMAR units). (B) Lesion size. (C) Central retinal thickness. (D) MD. (E) Foveal sensitivity.
Abbreviations: BCVA, best-corrected visual acuity; IVA, intravitreal aflibercept; logMAR, logarithm of minimal angle of resolution; MD, mean deviation.

Table 1 Characteristics at baseline and 12 months after the aflibercept treatment in neovascular AMD patients

	Baseline	12 months	P-value
Gender
Male, n (%)	19 (76%)
Female, n (%)	6 (24%)
Age (years)
Mean±SD	70.0±7.0
Subtype
tAMD/PCV	10/15
Lesion size (m^2)
Mean±SD	7.32±4.14	4.21±6.07	0.0090
CRT (μm)
Mean±SD	382.1±95.6	282.5±43.2	<0.0001
BCVA (logMAR)
Mean±SD	0.20±0.23	0.07±0.18	0.0001
Foveal sensitivity (dB)
Mean±SD	29.0±5.1	32.6±3.2	0.0009
PED, n (%)	18 (72.0)	5 (20.0)	<0.0001
IRF or SRF (%)	22 (88.0)	3 (12.0)	0.0015
SMH (%)	10 (40.0)	2 (8.0)	0.0041

Abbreviations: AMD, age-related macular degeneration; BCVA, best-corrected visual acuity; CRT, central retinal thickness; IRF, intraretinal fluid; logMAR, logarithm of minimal angle of resolution; PCV, polypoidal choroidal vasculopathy; PED, pigment epithelium detachment; SMH, submacular hemorrhage; SRF, subretinal fluid; tAMD, typical age-related macular degeneration.

Figure 3 Scatterplots showing the relationship between change in lesion size over 12 months and change in MD for each treated eye.

Abbreviation: MD, mean deviation.

Figure 4 Grade of ELM and EZ of eyes with neovascular age-related macular degeneration treated with IVA injections over a 12-month period.

Note: Assessments were made before the IVA and 6 and 12 months after the IVA.
Abbreviations: ELM, external limiting membrane; EZ, ellipsoid zone; IVA, intravitreal aflibercept.

Figure 5 (A) Scatterplots showing the relationship between final best-corrected visual acuity (logMAR units) and baseline foveal threshold (dB) for each treated eye. (B) Scatterplots showing the relationship between final best-corrected visual acuity (logMAR units) and baseline integrity of the ELM for each treated eye.

Abbreviations: BCVA, best-corrected visual acuity; ELM, external limiting membrane; logMAR, logarithm of minimal angle of resolution.

Table 2 Correlation between final best-corrected visual acuity in logMAR units and parameters

Parameter	Baseline			6 months			12 months
	FS	ELM	EZ	FS	ELM	EZ	FS	ELM	EZ
P-value	0.0428	0.0376	0.1264	0.0005	0.0275	0.017	0.0003	0.0362	0.0403
R	−0.4082	−0.4179	−0.3140	−0.6441	−0.4406	−0.4957	−0.6635	−0.4209	−0.4127

Abbreviations: ELM, external limiting membrane; EZ, ellipsoid zone; FS, foveal sensitivity; logMAR, logarithm of minimal angle of resolution.