Evaluation of contrast sensitivity and other visual function outcomes in diabetic macular edema patients following treatment switch to aflibercept from ranibizumab

Figures & data

Table 1 Inclusion and exclusion criteria

Inclusion criteria	Exclusion criteria
Informed consent	Intraocular pressure >25 mmHg
≥18 years of age	Prior retinal surgery or significant subretinal scarring, cataracts, or vitreous hemorrhage
Ability to complete study	Anti-VEGF treatment within prior 30 days
≥3 ranibizumab injections over previous 6 months	Intravitreal steroid treatment within prior 6 months
Persistent fluid on OCT	MI, TIA, or CVA within prior 90 days
Baseline fluorescein angiography	Current pregnancy or lactation
VA >6/30

Abbreviations: CVA, cerebrovascular accident; MI, myocardial infarction; OCT, optical coherence tomography; TIA, transient ischemic attack; VA, visual acuity; VEGF, vascular endothelial growth factor.

Table 2 Demographics and characteristics of patients at baseline (N=40)

Subject characteristics	Mean	SD	Range
Age (years)	70.3	11.3	41–88
Previous ranibizumab injection	21.1	11.9	5–55
Duration of prior ranibizumab therapy (months)	30.1	16.5	6–68
Number of ranibizumab injections over previous 6 months	5.5		5–6
Male (%)	65.0

Figure 1 Mean log contrast sensitivity at baseline and week 20.

Notes: *Indicates the mean value. Difference between mean log contrast sensitivity at week 20 and at baseline was statistically significant: P<0.001.

Figure 2 Mean logMAR best-corrected visual acuity at baseline and week 20. Notes: *Indicates the mean value. Difference between mean logMAR BCVA at week 20 and at baseline was statistically significant: P=0.0016.

Abbreviations: BCVA, best-corrected visual acuity; logMAR, logarithm of minimum angle of resolution.

Figure 3 Mean central retinal thickness at baseline and week 20.

Notes: *Indicates the mean value. Difference between mean CRT at week 20 and at baseline was statistically significant: P<0.001.
Abbreviation: CRT, central retinal thickness.

Figure 4 Change in log contrast sensitivity versus change in central retinal thickness at week 20.

Note: Relationship between change in CS and change in CRT was statistically significant: P<0.001.
Abbreviations: CRT, central retinal thickness; CS, contrast sensitivity.

Figure 5 Change in logMAR best-corrected visual acuity versus change in central retinal thickness at week 20.

Note: Relationship between change in BCVA and change in CRT was statistically significant: P=0.032.
Abbreviations: BCVA, best-corrected visual acuity; CRT, central retinal thickness; logMAR, logarithm of minimum angle of resolution.