Early centripetal displacements of capillaries in macular region caused by internal limiting membrane peeling

Figures & data

Figure 1 Pre- and postoperative OCTA image showing the FAZ and four polygonal areas surrounding the fovea.

Notes: (A) Preoperative image. (B) Postoperative image. All areas decreased after the surgery, and the shapes of the corresponding polygonal areas are very similar pre- and postoperatively.
Abbreviations: OCTA, optical coherence tomography angiography; FAZ, foveal avascular zone.

Table 1 Demographics of the patients and their characteristics before and after the surgery

Case no	Age (years)	Sex	Eye	Disease	PVD	Lens	ILM	Gas	FAZ area (mm^2)		P-F distance (mm)
									Preoperative	Postoperative	Preoperative	Postoperative
1	69	F	R	VMT	Absence	Phakia	Peeled	No	0.44	0.18	4.11	3.98
2	70	M	L	VMT	Absence	Phakia	Peeled	No	0.45	0.20	3.40	3.33
3	72	M	L	VMT	Absence	Phakia	Peeled	No	0.42	0.20	3.99	3.87
4	58	F	R	Thin ERM	Presence	Phakia	Peeled	No	0.34	0.21	4.93	4.74
5	72	F	R	Thin ERM	Presence	Phakia	Peeled	No	0.41	0.18	4.16	3.88
6	80	M	R	VMT	Absence	Phakia	Peeled	No	0.17	0.13	3.50	3.37
7	56	F	L	VMT	Absence	IOL	Peeled	Air	0.32	0.26	3.35	3.31
8	58	F	L	Thin ERM	Presence	Phakia	Peeled	No	0.32	0.15	NA	NA
9	58	M	R	RD	Presence	Phakia	Peeled	SF6	0.16	0.058	2.98	2.97
10	66	M	L	Thin ERM	Presence	Phakia	Peeled	No	0.15	0.070	3.28	3.12
11	63	F	R	RD	Presence	Phakia	Peeled	SF6	NA	NA	4.59	4.49
12	50	M	R	RD	Presence	Phakia	Peeled	SF6	NA	NA	4.29	3.91
13	70	M	L	VMT	Absence	Phakia	Reserved	Air	0.36	0.33	3.78	3.76
14	85	M	L	VMT	Absence	IOL	Reserved	No	0.45	0.44	3.71	3.72
15	72	M	L	VMT	Absence	Phakia	Reserved	No	0.24	0.26	3.27	3.27
16	58	F	L	VMT	Absence	Phakia	Reserved	Air	0.30	0.29	3.63	3.67
17	72	F	R	VMT	Absence	Phakia	Reserved	No	0.59	0.59	4.27	4.22
18	72	F	L	VMT	Absence	Phakia	Reserved	No	0.65	0.60	4.41	4.45

Abbreviations: PVD, posterior vitreous detachment; ILM, internal limiting membrane; FAZ, foveal avascular zone; P-F, papillofoveal; VMT, vitreomacular traction; ERM, epiretinal membrane; IOL, intraocular lens; RD, retinal detachment; SF6, sulfur hexafluoride gas; NA, not available; F, female; M, male; R, right; L, left.

Figure 2 Sequential changes in the FAZ area during the follow-up period (n=6).

Notes: The course of the postoperative decrease of the FAZ area can be fit by a hyperbolic curve in all cases (circle, Case 1; upward triangle, Case 2; downward triangle, Case 3; plus, Case 4; square, Case 5; diamond, Case 6).
Abbreviation: FAZ, foveal avascular zone.

Table 2 A hyperbolic curve from the course of the postoperative decrease of the FAZ area

Case no	Equation	R^2
1	y=0.419−0.270x/(0.812+x)	0.997
2	y=0.309−0.151x/(1.262+x)	0.969
3	y=0.340−0.190x/(1.347+x)	0.997
4	y=0.337−0.138x/(1.619+x)	0.993
5	y=0.410−0.234x/(1.040+x)	0.998
6	y=0.320−0.185x/(0.887+x)	0.986

Abbreviation: FAZ, foveal avascular zone.

Figure 3 Association between pre- and postoperative FAZ areas and polygonal areas in the ILM-peeled eyes (n=7).

Notes: (A) The pre- and postoperative five areas can be fit by a regression line in all cases (circle, Case 1; plus, Case 4; square, Case 5; diamond, Case 7; downward triangle, Case 8; upward triangle with square, Case 9; star, Case 10). (B) The pre- and postoperative five imaginary radii can also be fit by a regression line in all cases (circle, Case 1; plus, Case 4; square, Case 5; diamond, Case 7; downward triangle, Case 8; upward triangle, Case 9; star, Case 10).
Abbreviations: FAZ, foveal avascular zone; ILM, internal limiting membrane.

Table 3 A linear regression line from the pre- and postoperative five areas

Case no	Equation	R^2
1	y=0.953x−0.329	0.999
4	y=0.889x−0.284	0.985
5	y=0.890x−0.256	0.998
7	y=0.882x−0.152	0.999
8	y=0.941x−0.201	0.999
9	y=0.854x−0.172	0.998
10	y=0.922x−0.137	0.998

Table 4 A regression line from the pre- and postoperative five imaginary radii

Case no	Equation	R^2
1	y=1.073x−0.167	1.000
4	y=1.004x−0.116	1.000
5	y=1.021x−0.122	1.000
7	y=0.974x−0.068	1.000
8	y=1.040x−0.113	1.000
9	y=0.974x−0.091	1.000
10	y=0.984x−0.054	0.999

Table 5 Association between pre- and postoperative distance from the foveal center

Case no	Points measured	Equation	R^2
1	70	y=1.052x−0.157	0.986
4	59	y=1.021x−0.149	0.972
5	65	y=1.041x−0.154	0.973
6	60	y=1.017x−0.107	0.996
7	84	y=1.000x−0.101	0.992
8	62	y=1.037x−0.124	0.996

Figure 4 Corresponding positions of bifurcations of the capillaries from pre- and postoperative 6×6 mm OCTA en face images including fovea and disc in Case 6.

Notes: (A) Pre- and (B) postoperative images. Red, preoperative; blue, postoperative. Composite images were made by overlapping pre- and postoperative positions of the bifurcations. Centering in the (C) foveal center and (E) center of the disc center. Red and blue points were extracted for centering (D) in the foveal center and (F) in the disc center (F).
Abbreviation: OCTA, optical coherence tomography angiography.

Figure 5 The association between pre- and postoperative distance from the foveal center or the disc center in Case 6.

Notes: (A) Centering in the foveal center. The pre- and postoperative distance can be fit by a regression line (y=1.017x−0.107; R²=0.996). (B) Centering in the disc center. The pre- and postoperative distance can be fit by a regression line (y=0.956x+0.024; R²=0.997).