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Clinical Ophthalmology Volume 12, 2018 - Issue
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Original Research

Cone photoreceptor macular function and recovery after photostress in early non-exudative age-related macular degeneration

John D Rodriguez1 Ora, Inc., Andover, MA, USA, [email protected]Correspondence[email protected]
,
Keith Lane1 Ora, Inc., Andover, MA, USA, [email protected]
,
David A Hollander1 Ora, Inc., Andover, MA, USA, [email protected];2 Jules Stein Eye Institute, University of California, Los Angeles, CA, USA
,
Aron Shapiro1 Ora, Inc., Andover, MA, USA, [email protected]
,
Sunita Saigal1 Ora, Inc., Andover, MA, USA, [email protected]
,
Andrew J Hertsenberg1 Ora, Inc., Andover, MA, USA, [email protected]
,
Garrick Wallstrom3 Statistics and Data Corporation, Tempe, AZ, USA
,
Divya Narayanan1 Ora, Inc., Andover, MA, USA, [email protected]
,
Endri Angjeli1 Ora, Inc., Andover, MA, USA, [email protected]
&
Mark B Abelson1 Ora, Inc., Andover, MA, USA, [email protected];4 Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
 show all
Pages 1325-1335 | Published online: 27 Jul 2018

Figures & data

Figure 1 Exponential model parameters.

Note: Three-parameter exponential model showing the baseline cone threshold (c), recovery half-life (h), and intercept (a) used to fit cone data.
Figure 1 Exponential model parameters.

Table 1 Demographics of the subject population

Figure 2 Threshold data and least squares fit exponential model.

Note: Threshold data and least squares fit exponential model for AMD subject R2 values (0.91, 0.93, and 0.88) and for older normal subject R2 values (0.89, 0.92, and 0.91) for visits 2, 3, and 4, respectively.
Abbreviation: AMD, age-related macular degeneration.
Figure 2 Threshold data and least squares fit exponential model.

Figure 3 Baseline cone threshold.

Notes: ANOVA with the Satterthwaite approximation and Tukey–Kramer p-value adjustment was used to compare normal young and old subjects as well as age-matched older normal and AMD subjects. Scatterplot with error bars representing the standard deviation.
Abbreviations: AMD, age-related macular degeneration; ANOVA, analysis of variance.
Figure 3 Baseline cone threshold.

Figure 4 Recovery half-life.

Notes: ANOVA with the Satterthwaite approximation and Tukey–Kramer p-value adjustment was used to compare normal young and old subjects as well as age-matched older normal and AMD subjects. Scatterplot with error bars representing the standard deviation.
Abbreviations: AMD, age-related macular degeneration; ANOVA, analysis of variance.
Figure 4 Recovery half-life.

Figure 5 Baseline cone threshold change for repeated subjects.

Notes: Baseline cone threshold means were compared from the baseline year to the 1-year follow-up using Satterthwaite ANOVA; error bars represent the standard deviation.
Abbreviations: AMD, age-related macular degeneration; ANOVA, analysis of variance.
Figure 5 Baseline cone threshold change for repeated subjects.

Figure 6 Recovery half-life change for repeated subjects.

Notes: Recovery half-life means were compared from baseline year to 1-year follow-up using Satterthwaite ANOVA; error bars represent the standard deviation.
Figure 6 Recovery half-life change for repeated subjects.

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