Ocular hypotensive effects of prostaglandin analogs in Japanese patients with normal-tension glaucoma: a literature review

Figures & data

Table 1 List of studies included in Category 1

Study	PGA	Number of patients	Evaluation period	Study design	Endpoint(s)
Naito et al^Citation18	Travoprost	30	12 weeks	Single-arm	IOP
Inoue et al^Citation15	Latanoprost	18	3 months	Single-arm	IOP
Okada et al^Citation21	Tafluprost	42	6 months	Single-arm	IOP
Sone et al^Citation22	Tafluprost	38	12 weeks	Single-arm	IOP
Arai et al^Citation20	Bimatoprost	54	6 months	Single-arm	IOP
Nakano et al^Citation23	Tafluprost	41	12 weeks	Single-arm	IOP
Miyagawa et al^Citation24	Tafluprost	30	12 weeks	Single-arm	IOP
Kuwayama and Komemushi^Citation25	Tafluprost	48	4 weeks	RCT	IOP
Nagashima et al^Citation19	Travoprost	66	6 months	Single-arm	IOP
Kimura et al^Citation16	Latanoprost	43	3 months	Single-arm	IOP
Iwata et al^Citation17	Latanoprost	42	12 weeks	Single-arm	IOP

Abbreviations: IOP, intraocular pressure; PGA, prostaglandin analog; RCT, randomized controlled trial.

Table 2 List of studies included in Category 2

Study	PGA	Number of patients	Evaluation period	Study design	Endpoint(s)
Naito et al^Citation18	Travoprost	30	12 weeks	Single-arm	IOP reduction
Inoue et al^Citation26	Latanoprost	40	3 months	Four-arm	IOP
	Travoprost	64
	Tafluprost	52
	Bimatoprost	53
Mizoue et al^Citation38	Travoprost	103	12 weeks	Single-arm	IOP
Ko et al^Citation35	Latanoprost	60	3 months	Single-arm	IOP
Mizoguchi et al^Citation39	Tafluprost	90	12 weeks	Crossover	Diurnal IOP
	Travoprost	90
Tanabe et al^Citation40	Travoprost	49	3 months	Non-RCT	IOP
	Tafluprost	38
	Bimatoprost	27
Arai et al^Citation20	Bimatoprost	54	6 months	Single-arm	IOP
Nakano et al^Citation23	Tafluprost	41	12 weeks	Single-arm	IOP
Inoue et al^Citation15	Latanoprost	18	3 months	Single-arm	IOP
Okada et al^Citation21	Tafluprost	42	6 months	Single-arm	IOP
Sone et al^Citation22	Tafluprost	38	12 weeks	Single-arm	IOP
Nagashima et al^Citation19	Travoprost	66	6 months	Single-arm	IOP
Sunanaga and Kawano^Citation36	Latanoprost	52	6 months	Single-arm	IOP
Nomura et al^Citation41	Travoprost	17	1 or 2 months	Single-arm	Diurnal IOP
Kuwayama and Komemushi^Citation25	Tafluprost	48	4 weeks	RCT (2 arms)	IOP
Sugiyama et al^Citation37	Latanoprost	15	2 months	Run-in of non-RCT	ONH blood flow
Nakamoto and Yasuda^Citation27	Latanoprost	20	8 weeks	Run-in of RCT	Diurnal IOP
Ishibashi et al^Citation32	Latanoprost	22	More than 12 weeks	Single-arm	Diurnal IOP
Hashimoto et al^Citation33	Latanoprost	32	4 weeks	Single-arm	IOP
Ishibashi et al^Citation31	Latanoprost	16	More than 3 months	Single-arm	IOP
Hashimoto et al^Citation34	Latanoprost	21	6 months	Single-arm	IOP
Nakamoto et al^Citation30	Latanoprost	25	More than 8 weeks	RCT (2 arm)	Diurnal IOP
Nakamoto et al^Citation29	Latanoprost	23	More than 8 weeks	Single-arm	Diurnal IOP
Kimura et al^Citation16	Latanoprost	43	3 months	Single-arm	IOP
Nakamoto et al^Citation28	Latanoprost	25	4 weeks	Single-arm	IOP and ONH blood flow

Abbreviations: IOP, intraocular pressure; ONH, optic nerve head; PGA, prostaglandin analog; RCT, randomized controlled trial.

Figure 1 Selection of articles outlined according to PRISMA guidelines.

Notes: Some articles covered multiple topics that were excluded.
Abbreviations: IOP, intraocular pressure; NTG, normal-tension glaucoma; PGA, prostaglandin analogs.

Figure 2 Weighted ocular hypotensive efficacy of prostaglandin analogs calculated using data from the studies in Category 1.

Note: Data are presented as weighted mean ± SD.

Figure 3 Scatter plot analysis of studies in Category 2 as a function of predosing IOP values.

Abbreviation: IOP, intraocular pressure.

Figure 4 Scatter plot analysis of studies in Category 2 as a function of (A) IOP reduction and (B) percentage IOP reduction.

Abbreviation: IOP, intraocular pressure.

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