Macular laser photocoagulation guided by spectral-domain optical coherence tomography versus fluorescein angiography for diabetic macular edema

Figures & data

Figure 1 Example of fluorescein angiography guidance of macular laser photocoagulation (A) showing the leaking area of the macula (surrounded by arrowheads). The equivalent color fundus photograph (B) is used to show the laser spot location mapping (blue asterisks).

Figure 2 Example of spectral-domain optical coherence tomography (SD-OCT) guidance of macular laser photocoagulation. Retinal thickness color map (A) obtained by SD-OCT software; a fundus photograph (B) is also registered; finally, a composition of the map superimposed and aligned on the fundus image is provided automatically by SD-OCT (C). The equivalent color fundus photograph (D) is used to show the laser spot location mapping (blue asterisks) avoiding the foveal area.

Table 1 Baseline and endpoint characteristics of patients assigned to macular laser photocoagulation guided by fluorescein angiography findings

Patient no	Gender	Age	Eye no	BCVA (logMAR)		CMT (μm)		RV(mm^3)
				Baseline	Endpoint	Baseline	Endpoint	Baseline	Endpoint
1	F	62	1	0.4	0.4	301	275	10.9	10.1
2	F	67	2	0.2	0.2	334	344	11.0	10.9
			3	0.3	0.3	424	396	10.6	10.5
3	F	56	4	0.2	0.1	244	213	8.6	8.4
4	F	51	5	0.7	0.4	170	164	11.2	9.6
			6	0.5	0.5	195	180	11.7	11.9
5	M	62	7	0.5	0.4	272	244	10.6	10.6
			8	0.5	0.4	387	321	11.3	10.6
6	M	54	9	0.7	0.5	439	298	14.4	13.1
7	M	71	10	0.8	0.5	740	589	13.6	11.9
			11	0.4	0.2	567	344	12.8	10.9
8	F	72	12	0.3	0.1	353	290	11.6	10.7
			13	0.5	0.5	422	413	11.3	10.6
9	M	69	14	0.5	0.3	375	327	10.6	10.3
			15	0.5	0.3	396	316	10.5	10.1
10	M	48	16	0.4	0.4	472	493	12.8	12.8
			17	1	0.7	579	369	14.1	13.4
11	M	66	18	0.4	0.2	357	297	10.7	9.5
			19	0.5	0.2	352	303	9.8	9.6
12	M	61	20	1	0.7	566	494	14.1	13.2

Abbreviations: FA, fluorescein angiography; F, female; M, male; BCVA, best-corrected visual acuity; CMT, central macular thickness; RV, retinal volume.

Table 2 Baseline and endpoint characteristics of the patients assigned to macular laser photocoagulation guided by SD-OCT retinal thickness map

Patient no	Gender	Age	Eye no	BCVA (logMAR)		CMT (μm)		RV (mm^3)
				Baseline	Endpoint	Baseline	Endpoint	Baseline	Endpoint
13	M	63	21	0.8	0.5	428	338	13.9	12.3
14	F	64	22	1	0.8	875	562	17.9	14.0
			23	0.8	0.5	647	319	14.9	12.3
15	M	55	24	0.4	0.4	358	332	8.8	8.6
16	M	52	25	0.7	0.3	519	341	13.7	12.2
			26	0.4	0.2	456	207	12.8	11.1
17	M	74	27	0.3	0.2	276	242	10.3	9.6
			28	0.5	0.5	423	311	12.9	11.5
18	M	65	29	0.5	0.4	310	288	13.7	12.8
			30	0.4	0.3	454	326	11.3	10.9
19	F	57	31	0.3	0.2	324	256	11.8	10.9
			32	0.3	0.2	355	294	11.7	10.6
20	M	41	33	0.2	0.1	278	219	12.1	11.7
			34	0.3	0.3	296	234	10.4	9.9
21	F	76	35	0.4	0.2	394	313	10.5	10.1
			36	0.2	0.1	302	287	10.2	10.1
22	M	68	37	0.7	0.4	572	345	14.5	11.5
			38	0.7	0.5	563	538	13.2	12.5
23	F	63	39	0.3	0.1	335	315	11.1	9.4
24	M	75	40	0.4	0.3	346	331	11.9	11.0

Abbreviations: SD OCT, spectral-domain optical coherence tomography; F, female; M, male; BCVA, best-corrected visual acuity; CMT, central macular thickness; RV, retinal volume.