Ocular hypotensive effect, preservation of visual fields, and safety of adding dorzolamide to prostaglandin therapy for twelve months

Figures & data

Figure 1 Intraocular pressure (IOP) before and after addition of dorzolamide.

Notes: *P < 0.0001, ANOVA and the Bonferroni/Dunnett tests.

Figure 2 Mean deviation at baseline and 12 months after addition of dorzolamide.

Note: Paired t-test.
Abbreviation: NS, not significant.

Table 1 Review of previous studies conducted outside/inside Japan

	Previous eye drops	Dorzolamide	Number of cases	Duration	Baseline IOP (mmHg)	Absolute reduction (mmHg)	Percent reduction (%)
O’Connor^Citation6	Latanoprost	2% (bid or tid)	25	1 year	19.8	3.9	19.7
Tamer^Citation7	Latanoprost	2% (bid)	36	4 weeks	19.9–23.3	2.6–3.2	12.5–14.7
Bournias^Citation8	Latanoprost	2% (tid)	40	4 months	20.3–21.9	2.8–3.4	13.3–15.5
	Travoprost
	Bimatoprost
Boyer^Citation9	Travoprost	2% (bid)	86	6 months	18.9 ± 4.2	3.9	20.6
Arici^Citation10	Latanoprost	2% (tid)	15	10 days	18.7 ± 2.3	2.8	15.0
Maruyama^Citation5	Latanoprost	1% (tid)	33	3 months	16.0 ± 2.1	1.0	6.3
Nakamura^Citation4	Latanopropt	1% (bid or tid)	20	4 weeks	20.0	2.4–4.8	12.0–24.0
Inoue^Citation11	Latanoprost	1%	55	6 months	16.7 ± 2.4	2.5–2.8	14.2–16.4
	Travoprost

Abbreviations: bid, twice daily; tid, three times daily; IOP, intraocular pressure.

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