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Original Research

Circumpapillary structure-function relationships with microperimetry and spectral domain optical coherence tomography in glaucoma: a pilot study

, , , , &
Pages 2535-2544 | Published online: 06 Dec 2018

Figures & data

Table 1 Demographics of participants

Figure 1 A typical example of a circumpapillary spectral-domain optical coherence tomography scan.

Notes: (A) Retinal layer boundaries were automatically detected by the image-segmentation algorithm. cpRNFL, cpGCC, cpOR, and cpTR thickness were measured. (B) Circumpapillary retinal layer sectors used for the analysis in the current investigation are shown. Retinal thickness measurements were performed around a 3.45 mm diameter circle.
Abbreviations: cpGCC, circumpapillary ganglion cell complex; cpOR, circumpapillary outer retina; cpRNFL, circumpapillary retinal nerve fiber; cpTR, circumpapillary total retina; I, inferior; N, nasal; S, superior; T, temporal.
Figure 1 A typical example of a circumpapillary spectral-domain optical coherence tomography scan.

Figure 2 A typical example of a normal eye.

Notes: Color fundus photograph (A). Humphrey 30-2 Swedish interactive threshold-algorithm visual field: (B) gray scale; (C) threshold-sensitivity values. The 12 cpRNFL (D), cpGCC (E), cpOR (F), and cpTR (G) sectors. The 12 circumpapillary microperimetry-sensitivity sectors (H) of the normal right eye of a 46-year-old male subject.
Abbreviations: cpGCC, circumpapillary ganglion cell complex; cpOR, circumpapillary outer retina; cpRNFL, circumpapillary retinal nerve fiber; cpTR, circumpapillary total retina.
Figure 2 A typical example of a normal eye.

Figure 3 A typical example of a glaucoma eye.

Notes: Color fundus photograph (A). Humphrey 30-2 Swedish interactive threshold-algorithm visual field: (B) gray scale; (C) threshold-sensitivity values. The 12 cpRNFL (D), cpGCC (E), cpOR (F), and cpTR (G) sectors. The 12 circumpapillary microperimetry-sensitivity sectors (H) of the glaucomatous left eye of a 60-year-old female primary open-angle glaucoma patient. Inferotemporal structural damage (neuroretinal rim loss on A and RNFL thinning on D) corresponded spatially with the superior Bjerrum scotoma shown by the Humphrey visual field (B, C). The circumpapillary microperimetry test (H) showed significant inferotemporal sensitivity reduction around the disk.
Abbreviations: cpGCC, circumpapillary ganglion cell complex; cpOR, circumpapillary outer retina; cpRNFL, circumpapillary retinal nerve fiber; cpTR, circumpapillary total retina.
Figure 3 A typical example of a glaucoma eye.

Table 2 Comparison of various circumpapillary retinal thickness sectors between groups

Table 3 Comparison of circumpapillary retinal sensitivity between groups

Table 4 Correlation between circumpapillary retinal thickness parameters and the corresponding retinal sensitivity thresholds in total population (n=36)

Figure 4 Scatterplots of associations between visual field mean deviation and superotemporal and inferotemporal circumpapillary retinal sensitivity.

Notes: (A) Relationship between circumpapillary retinal sensitivity determined for sector 1 (superotemporal sector) and mean deviation. (B) Relationship between circumpapillary retinal sensitivity determined for sector 5 (inferotemporal sector) and mean deviation. Significant correlations were found for both sectors (sector 1, r=0.470; P=0.04; sector 5; r=0.685, P<0.001).
Figure 4 Scatterplots of associations between visual field mean deviation and superotemporal and inferotemporal circumpapillary retinal sensitivity.