Effect of bilberry extract on slowing high-myopia progression in children: 2-year follow-up study

Figures & data

Table 1 Refraction at baseline and 6-month intervals

	Group 1 (Difrarel)	Group 2 (control)	P-value
Baseline	−10.78±2.6	−10.5±2.55	0.7
After 6 months	−11±2.6	−10.9±2.7	0.2
After 12 months	−11.05±2.6	−11.56±2.6	0.04a
After 18 months	−11.14±2.7	−11.9±2.6	0.02a
After 24 months	−11.17±2.5	−12.3±2.6	0.01a

Note:

a P<0.05.

Table 2 Axial length at baseline and 6-month intervals

	Group 1 (Difrarel)	Group 2 (control)	P-value
Baseline	23.7±1.2	23.9±1.4	0.4
After 6 months	23.76±1.24	24.27±1.4	0.1
After 12 months	23.85±1.23	24.5±1.4	0.04a
After 18 months	23.87±1.2	24.67±1.5	0.02a
After 24 months	23.9±1.2	24.8±1.5	0.008a

Note:

a P<0.05.

Table 3 Differences in refraction and axial length at different follow-up intervals

Variables	Group 1 (Difrarel)	Group 2 (control)	Difference	P-value
Difference between baseline and 6 months
Refraction	0.01±0.05	0.15±0.1	33%	0.001a
Axial length	0.22±0.2	0.39±0.2	43%	0.004a
Difference between baseline and 12 months
Refraction	0.12±0.08	0.39±0.16	69%	0.001a
Axial length	0.26±0.17	1.03±0.3	74%	0.001a
Difference between 12 and 18 months
Refraction	0.05±0.06	0.16±0.07	69%	0.001a
Axial length	0.1±0.12	0.4±0.12	75%	0.01a
Difference between 12 and 24 months
Refraction	0.1±0.06	0.3±0.1	67%	0.03a
Axial length	0.2±0.1	0.76±0.19	74%	0.001a

Note:

a P<0.05.