Short-term effect of topical antiglaucoma medication on tear-film stability, tear secretion, and corneal sensitivity in healthy subjects

Figures & data

Figure 1 Relative changes in break-up time of brimonidine, latanoprost, apraclonidine, dorzolamide, the fixed dorzolamide/timolol combination, and timolol 60 minutes before (T−60) and 30 (T+30), 60 (T+60), and 90 (T+90) minutes after drop application.

Notes: *P < 0.05; **P < 0.01.
Abbreviation: BUT, break-up time.

Figure 2 Relative changes in break-up time of BAK 0.02%, BAK 0.005%, and sodium chloride 0.9% 60 minutes before (T−60) and 30 (T+30), 60 (T+60), and 90 (T+90) minutes after drop application.

Note: *P < 0.05.
Abbreviations: BUT, break-up time; BAK, benzalkonium chloride.

Figure 3 Relative changes of basal secretion of brimonidine, latanoprost, apraclonidine, dorzolamide, the fixed combination dorzolamide/timolol and timolol 60 minutes before (T−60) and 30 (T+30), 60 (T+60) and 90 (T+90) minutes after drop application.

Notes: *P < 0.05; **P < 0.01; ***P < 0.001.
Abbreviation: BS, basal secretion.

Figure 4 Relative changes of basal secretion of BAK 0.02%, BAK 0.005% and sodium chloride 0.9% 60 minutes before (T−60) and 30 (T+30), 60 (T+60), and 90 (T+90) minutes after drop application.

Note: **P < 0.01.
Abbreviations: BS, basal secretion; BAK, benzalkonium chloride.

Figure 5 Relative changes of corneal sensitivity of brimonidine, latanoprost, apraclonidine, dorzolamide, the fixed combination dorzolamide/timolol and timolol 60 minutes before (T−60) and 5 (T+5), 10 (T+10) and 15 (T+15) minutes after drop application.

Note: *P < 0.05.

Figure 6 Relative changes of corneal sensitivity of BAK 0.02%, BAK 0.005% and sodium chloride 0.9% 60 minutes before (T−60) and 5 (T+5), 10 (T+10) and 15 (T+15) minutes after drop application.