The effects of temporary intraocular pressure spikes after intravitreal dexamethasone implantation on the retinal nerve fiber layer

Figures & data

Figure 1 Ozurdex^® injector (left) and pellet (right).

Figure 2 Above is a summary of the mean IOP between treatment and control arms stratified by diagnosis at the time of IOP spike in the cross-sectional group. P-value was <0.05 for each diagnosis. Other = wAMD and CME.

Abbreviations: BRVO, branch retinal vein occlusion; DME, diabetic macular edema; CRVO, central retinal vein occlusion; wAMD, wet age-related macular degeneration; CME, cystoid macular edema; IOP, intraocular pressure; POHx, past ocular history.

Table 1 Demographic data

Demographics (n=48 patients – 96 eyes)
Age (yrs)		72.7±10.9
Sex	Male	51%
	Female	49%
Race
	White	57%
	Hispanic	29%
	Black	1%
	Other	13%
Diagnosis
	BRVO	34%
	DME	25%
	CRVO	23%
	Uveitis	6%
	CME	6%
	wAMD	4%

Abbreviations: BRVO, branch retinal vein occlusion; DME, diabetic macular edema; CRVO, central retinal vein occlusion; wAMD, wet age-related macular degeneration; CME, cystoid macular edema.

Figure 3 Above is a summary of the mean RNFL thicknesses between treatment and control arms stratified by diagnosis. P-value was >0.05 for each diagnosis. Other = wAMD and CME.

Abbreviations: BRVO, branch retinal vein occlusion; DME, diabetic macular edema; CRVO, central retinal vein occlusion; wAMD, wet age-related macular degeneration; CME, cystoid macular edema; POHx, past ocular history; RNFL, retinal nerve fiber layer.

Figure 4 Above summarizes the mean RNFL differences between treatment and control arms stratified by the magnitude of IOP elevation as well as those treated eyes with IOP spikes ≥10 mmHg from baseline IOP. P-value was >0.05 for each group.

Abbreviations: IOP, intraocular pressure; RNFL, retinal nerve fiber layer; BL, baseline; Avg, average.