Treatment of central serous chorioretinopathy with topical NSAIDs

Figures & data

Figure 1 Central serous retinopathy (CSCR) patients in treatment and control groups both had comparable visual acuity and central macular thickness at the initial presentation. There is no statistical significance between the two groups. Bars represent mean ± standard error of the mean.

Abbreviation: ETDRS, Early Treatment Diabetic Retinopathy Study.

Figure 2 The percentage reduction is calculated as [(Original volume – Follow-up volume)]/(Original Volume)*100%, and incorporated as bar graphs with increments of 10% ranging from “0%” to “100%”. Each bar graph represents the number of patients in that percentage group range. In comparison to the control group, patients in the treatment group had higher tendencies for having full resolution of central serous chorioretinopathy (CSCR). The majority of patients in the control/observation group, on the other hand, had no or minimal improvement in the subretinal fluid volume at follow-up visit.

Figure 3 Panel A – central macular thickness reductions in the control and treatment groups were 43.5 µm and 196.2 µm, respectively (p<0.006). Panel B – percentage reductions of subretinal fluid volume were 11.1% and 64.3% in the control and treatment groups, respectively (p<0.02). Bars represent mean ± standard error of the mean.

Figure 4 Changes in the visual acuity score were 0.69 letters for the control group and 5.2 letters for the treatment group (p-value=0.067). Bars represent mean ± standard error of the mean.

Abbreviation: ETDRS, Early Treatment Diabetic Retinopathy Study. 

Table 1 Clinical characteristics of patients who were either treated or observed for acute central serous chorioretinopathy

Patient number	Sex	Age	Management approach	Initial central macular thickness (μm)	Follow-up central macular thickness (μm)	Follow-up period (days)
1	M	65	Observation	369	235	42
2	M	54	Observation	394	310	41
3	F	63	Observation	207	209	28
4	F	41	Observation	369	243	28
5	F	42	Observation	348	364	21
6	M	44	Observation	471	437	28
7	M	42	Observation	341	346	42
8	F	81	Observation	448	450	28
9	M	40	Observation	532	367	38
10	M	37	Observation	433	516	40
11	M	44	Observation	517	403	29
12	M	38	Observation	650	632	29
13	M	51	Observation	380	381	41
14	M	41	Xibrom	711	329	39
15	M	39	Xibrom	464	312	36
16	M	43	Xibrom	829	228	22
17	M	32	Nevanac	402	284	14
18	F	64	Nevanac	360	460	39
19	F	39	Nevanac	515	313	33
20	M	64	Nevanac	311	278	45
21	M	48	Nevanac	370	302	20
22	M	46	Nevanac	412	202	21
23	M	46	Nevanac	671	269	29
24	M	54	Ilevro	410	250	49
25	M	33	Ilevro	620	243	31
26	F	38	Ilevro	329	253	26
27	M	35	Ilevro	560	494	28