Comparison Of Surgical Outcomes Of 360° Circumferential Trabeculotomy Versus Sectoral Excisional Goniotomy With The Kahook Dual Blade At 6 Months

Figures & data

Table 1 Baseline Demographic And Glaucoma Status Data

	Trab360/GATT	KDB	P-value
Subject-Level Parameters	n=25	n=61
Age (years), mean ± SD	69.2 ± 9.2	68.5 ± 8.9	0.734
Gender, n (%)
Female	17 (68.0)	33 (54.1)	0.235
Male	8 (32.0)	28 (45.9)
Ethnicity, n (%)
Caucasian	19 (76.0)	45 (73.5)	0.908
Black	4 (16.0)	12 (19.8)
Other	2 (8.0)	4 (6.7)
Eye-Level Parameters	n=27	n=74
Glaucoma type, n (%)
Primary open-angle	21 (77.8)	44 (59.5)	0.196
Pseudoexfoliation	2 (7.4)	6 (8.1)
Other	4 (14.8)	24 (32.4)
Severity, n (%)
Mild	8 (29.6)	25 (33.8)	0.849
Moderate	2 (7.4)	7 (9.4)
Severe	17 (63.0)	42 (56.8)
Baseline IOP (mmHg), mean ± SD	18.3 ± 5.1	17.3 ± 4.8	0.348
Baseline medications, mean ± SD	2.5 ± 1.3	2.13 ± 1.3	0.193

Abbreviations: GATT, gonioscopy-assisted transluminal trabeculotomy; KDB, Kahook Dual Blade; SD, standard deviation; Other, normal tension glaucoma, uveitic, combined mechanism, neovascular, and traumatic.

Table 2 Surgical Success Rates (≥20% IOP Reduction Or ≥1 Medication Reduction Without Additional IOP-Lowering Procedures), Mean IOP, And Mean Medication Data For Both Groups At Each Time Point

	Baseline			Day 1			Week 1			Month 1			Month 3			Month 6
	KDB	Trab360/ GATT	P	KDB	Trab360/ GATT	P	KDB	Trab360/ GATT	P	KDB	Trab360/ GATT	P	KDB	Trab360/ GATT	P	KDB	Trab360/ GATT	P
Success, % (n)	–	–	–	–	–	–	66.7 (46/69)	79.2 (19/24)	0.253	64.4 (38/59)	81.5 (22/27)	0.111	74.1 (43/58)	78.3 (18/23)	0.695	81.7 (58/71)	84.6 (22/26)	0.737
IOP, mmHg
Mean (SD)	17.3 (4.8)	18.3 (5.1)	0.384	14.3 (5.9)	16.4 (7.5)	0.489	16.9 (7.1)	16.1 (7.2)	0.753	14.6 (4.2)	15.6 (4.6)	0.513	14.8 (3.9)	15.0 (6.0)	0.931	15.0 (3.5)	16.0 (3.9)	0.291
Mean reduction from baseline (SD)	–	–	–	3.3 (6.8)	3.2 (9.4)	0.686	2.0 (9.4)	0.2 (9.3)	0.539	5.6 (8.2)	2.7 (7.3)	0.814	5.7 (7.2)	5.5 (10.0)	0.596	2.9 (5.4)	2.9 (6.8)	0.417
Mean % reduction from baseline (SD)	–	–	–	16.5 (38.4)	8.5 (66.3)	0.283	6.6 (55.9)	13.3 (66.7)	0.806	29.1 (44.3)	0.2 (88.5)	0.253	31.9 (40.3)	19.3 (60.0))	0.250	13.0 (30.0)	6.2 (51.6)	0.137
Medications, #
Mean (SD)	2.1 (1.3)	2.5 (1.3)	0.193	1.7 (1.4)	0.2 (0.8)	<0.002	1.1 (1.5)	1.1 (1.6)	0.856	1.4 (1.4)	1.1 (1.5)	0.349	1.0 (1.2)	1.3 (1.5)	0.166	1.1 (1.3)	1.4 (1.4)	0.354
Mean reduction from baseline (SD)	–	–	–	0.5 (1.2)	2.3 (1.4)	<0.002	1.0 (1.5)	1.5 (1.5)	0.188	0.9 (1.4)	1.4 (1.4)	0.013	1.3 (1.4)	1.3 (1.2)	0.641	1.1 (1.6)	1.2 (1.1)	0.641
Mean % reduction from baseline (SD)	–	–	–	18.9 (45.5)	92.4 (25.5)	<0.002	46.3 (59.3)	63.0 (48.2)	0.368	43.0 (54.4)	58.3 (45.2)	0.0268	55.6 (52.2)	56.2 (4.4)	0.836	44.5 (73.0)	58.3 (45.2)	0.858

Notes: n, number of eyes, #, classes of IOP-lowering medications, P-values reflect between-group differences.

Figure 1 IOP for sectoral excisional goniotomy with KDB or Trab360/GATT in the 6-month follow-up period.

Figure 2 IOP-lowering medications for sectoral excisional goniotomy with KDB or Trab360/GATT in the 6-month follow-up period.

Table 3 The Nature And Frequency Of Adverse Events And Additional IOP-Lowering Procedures By Group, N (%)

	KDB (n=74)	Trab360/GATT (n=27)
Adverse Events
Cystoid macular edema	3 (4.1%)	3 (11.1%)
Hyphema (after Week 2)	2 (2.7%)	1 (1.4%)
Steroid-related IOP spike	0 (0%)	2 (7.4%)
Additional IOP-lowering Procedures
Trabeculoplasty	5 (6.8%)	5 (18.5)
MicroPulse^® Cyclophotocoagulation	1 (1.4%)	1 (3.7%)
Filtering surgery	1 (1.4%)	0 (0%)

Abbreviations: GATT, gonioscopy-assisted transluminal trabeculotomy; KDB, Kahook Dual Blades.