In vitro demodicidal activity of commercial lid hygiene products

Figures & data

Table 1 Common symptoms of Demodex-associated blepharitis

Common symptoms of Demodex-associated blepharitis^Citation16
Itching Burning Foreign body sensation Crusting of the lashes Redness of the eyelid margins Blurry vision

Table 2 In vitro kill time for Demodex in test solution

In vitro kill time for Demodex in test solution*
0.01% HOCl			100% MO			4% T4O
# of organisms		Kill time (minutes)	# of organisms		Kill time (minutes)	# of organisms		Kill time (minutes)
TRIAL 1	3	80	TRIAL 2	3	90	TRIAL 3	2	40
TRIAL 4	2	90	TRIAL 5	3	90	TRIAL 6	5	40
TRIAL 7^†	9	90	TRIAL 8^†	3	90	TRIAL 9^†	5	40
TOTAL	14	-	TOTAL	9	-	TOTAL	12	-
Mean (SD)
4.67 (3.79)		87.86 (4.23)	3 (1.00)		90 (0.00)	4 (1.73)		40 (0.00)

Notes: *P=0.03, adjusted H =7 (Kruskal–Wallis test); ^†Denotes those samples that were included in the maximum observed survival time calculations.

Figure 1 Demodex folliculorum mites on a lash follicle (black arrows).

Figure 2 Demodex-associated blepharitis with classic cylindrical dandruff (white arrows).

Figure 3 Maximum survival time for Demodex folliculorum mites by direct observation in test solutions.

Liu J, Sheha H, Tseng SC. Pathogenic role of Demodex mites in blepharitis. Curr Opin Allergy Clin Immunol. 2010;10(5):505–510. doi:10.1097/ACI.0b013e32833df9f4

 PubMed Web of Science ®Google Scholar