Selective serotonin reuptake inhibitors may lead to improved cataract surgery outcomes in patients with amblyopia

Figures & data

Table 1 Pre- and postoperative characteristics for patients in SSRI/SNRI and control group

Characteristic	SSRI/SNRI group	Control group
Age at surgery (years ± SD)	67.6±7.6	69.7±10.8
Pre-op VA (logMAR ± SD)	0.543±0.286	0.604±0.351
Post-op VA (logMAR ± SD)	0.266±0.190	0.411±0.322
Time between surgery and post-op VA measurement (years ± SD)	1.79±1.12	1.51±1.32
Males, n (%)	10 (26)	79 (40)
Females, n (%)	28 (74)	120 (60)

Abbreviations: SSRI, selective serotonin reuptake inhibitor; SNRI, serotonin norepinephrine reuptake inhibitor; VA, visual acuity.

Figure 1 Graph of improvement in visual acuity post-op.

Table 2 Multivariable regression model for factors affecting postoperative visual acuity

Parameter	β^*	95% CI	p
Time between surgery and postoperative VA measurement (years)	−1.60×10^–5	(−8.70×10^–5, 5.54×10^–5)	0.66
Age at surgery	6.55×10^–3	(3.34×10^–3, 9.77×10^–3)	<0.005
Baseline VA	−0.561	(−0.659. −0.463)	<0.005
SSRI/SNRI	−0.103	(−0.194, −0.0116)	0.03

Note: *β is the estimated beta-coefficient of the linear regression model.

Abbreviations: SSRI, selective serotonin reuptake inhibitor; SNRI, serotonin norepinephrine reuptake inhibitor; VA, visual acuity.