Effect of intravitreal dexamethasone solution on the reduction of macular thickness in pseudophakic diabetic patients in a public hospital in Brazil: a randomized clinical trial

Figures & data

Table 1 Baseline characteristics of 27 subjects with diabetic macular edema randomized to receive intravitreal 0.01 mL (40 μg), 0.03 mL (120 μg), or 0.05 mL (200 μg) of the 4 mg/mL dexamethasone solution

	40 μg (n=9)	120 μg (n=9)	200 μg (n=9)	P
Age (years): mean (SD), median	67 (6), 66	66 (8), 66	71 (7), 70	0.226^a
Sex – male	6	5	4	0.638^b
Eye – right	3	7	5	0.165^b
ERM	5	3	2	0.329^b
SRF	1	2	1	0.746^b
MA	8	8	9	0.583^b
PVD	2	2	5	0.223^b
CMT (µm): mean (SD), median	527 (154), 459	630 (255), 548	453 (140), 398	0.163^a
BCVA (letters): mean (SD), median	52 (14), 48	47 (19), 47	60 (15), 67	0.343^a
BCVA (Snellen)	≅0.20	≅0.16	≅0.32
IOP (mmHg): mean (SD), median	12 (2), 12	12 (3), 12	12 (3), 11	0.,270^a

Notes: ^aKruskal–Wallis one-way ANOVA, ^bFisher’s exact test. BCVA based on ETDRS charts.

Abbreviations: ERM, epiretinal membrane; SRF, subretinal fluid; MA, microaneurysms in foveal region; PVD, posterior vitreal detachment; CMT, central macular thickness; BCVA, best-corrected visual acuity; IOP, intraocular pressure; ETDRS, Early Treatment Diabetic Retinopathy Study.

Figure 1 Mean change and 95% CI in macular thickness from baseline over time for the overall cohort, in µm.

Abbreviation: D, days after injection.

Figure 2 Mean change and 95% CI in macular thickness from baseline over time for each group, in µm.

Abbreviation: D, days after injection.

Figure 3 Mean change and 95% CI in visual acuity from baseline over time for the overall cohort, in ETDRS letter score.

Abbreviations: D, days after injection; ETDRS, Early Treatment Diabetic Retinopathy Study.

Figure 4 Mean change and 95% CI in visual acuity from baseline over time for each group, in ETDRS letter score.

Abbreviations: D, days after injection; ETDRS, Early Treatment Diabetic Retinopathy Study.

Figure 5 Mean change and 95% CI in intraocular pressure (IOP) from baseline over time for the overall cohort, in mmHg.

Figure 6 Mean change and 95% CI in intraocular pressure (IOP) from baseline over time for each group, in mmHg.

Abbreviation: D, days after injection.