Quantitative Comparison Of Microvascular Metrics On Three Optical Coherence Tomography Angiography Devices In Chorioretinal Disease

Figures & data

Table 1 Comparison Of 3 OCT-A Devices

Device	Cirrus HD-OCT Angioplex	RTvue XR Avanti Angiovue	DRI OCT-1 Triton
Manufacturer	Carl Zeiss Meditec	Optovue	Topcon
OCTA Algorithm	OMAG	SSADA	OCTARA
Scanning Speed	68,000 A-scans/sec	70,000 A-scans/sec	100,000 A-scans/sec
Repeated B-scan Count	2 (6 x 6), 4 (3 x 3)	2	4
Motion correction	Real-time tracking	Real-time tracking and post-scan orthogonal registration	Real-time tracking
OCTA scanning protocols	3 x 3, 6 x 6 mm centered on macula	3 x 3, 6 x 6, 8 x 8 mm centered on macula	3 x 3, 4.5 x 4.5, 6 x 6 mm centered on either macula or optic nerve head
FDA Approval	Yes	Yes	No

Abbreviatons: OMAG, optical micro-angiography; SSADA, split-spectrum amplitude decorrelation angiography; OCTARA, OCTA ratio analysis.

Table 2 Patient Demographic Information And Chorioretinal Disease Diagnosis

Patient	Age & Gender	Eye	Diagnosis
1	81, F	R	Dry AMD
		L	Wet AMD
2	53, M	R	Aneurismal Type 1 NV
		L	CSR
3	80, M	R	CSR vs AMD
4	55, M	R	MacTel2
		L	MacTel2
5	67, M	R	AMD, quiescent CNVM
		L	AMD, quiescent CNVM
6	66, F	R	MacTel2
		L	MacTel2
7	68, F	R	Wet AMD
		L	Wet AMD/CSR

Abbreviations: AMD, age-related macular degeneration; Aneurismal Type 1 NV, aneurismal type 1 neovascularization; CSR, central serous retinopathy; MacTel2, macular telangiectasia type 2; CNVM, choroidal neovascular membranes.

Figure 1 SCP images and segmentation using Optovue RTVue-XR, Topcon DRI-OCT Triton Swept-Source OCT, and Zeiss Cirrus 5000-HD-OCT Angioplex.

Figure 2 SCP images after binarization using the Niblack automated local thresholding method.

Figure 3 (A) Bland-Altman plot showed agreement between the two investigators for the SCP FAZ area measurements. (B–D) Bland-Altman plot showing the level of agreement between FAZ area measurements for devices. (B) Triton vs Angiovue. (C) Triton vs Angioplex. (D) Angiovue vs Angioplex.

Table 3 SCP FAZ Measurements And ICC

Machine	SCP FAZ	ICC
Triton	0.161 ± 0.103
Angiovue	0.161 ± 0.106	0.95
Angioplex	0.164 ± 0.100

Table 4 SCP And DCP VD Measurements With Respect To Individual Devices From Binarized Images Using The Niblack Automated Local Thresholding Method

Machine	SCP Mean VD	DCP Mean VD
Triton	0.340 ± 0.014	0.334 ± 0.009
Angiovue	0.307 ± 0.013	0.332 ± 0.025
Angioplex	0.352 ± 0.014	0.364 ± 0.012

Table 5 Post Hoc Comparisons Of SCP VD, DCP VD, And FAZ

Machine			Mean Difference	SE	p value
Triton	Angiovue	SCP VD	0.033	0.003	< 0.001
		DCP VD	0.002	0.007	1
		FAZ	1.1e -4	0.005	1
Triton	Angioplex	SCP VD	−0.012	0.004	0.041
		DCP VD	−0.030	0.004	< 0.001
		FAZ	−0.003	0.006	1
Angiovue	Angioplex	SCP VD	−0.045	0.005	< 0.001
		DCP VD	−0.032	0.008	0.006
		FAZ	−0.004	0.006	1