Anterior chamber angle in aniridia with and without glaucoma

Figures & data

Table 1 Characteristics of aniridia patients (N=43)

Number of patients	43
Number of eyes	86
Gender, male/female, N (%)	18/25 (42/58%)
Mean age±SD (median age), years	30.8±17.9
Race, Caucasian/Asian, N (%)	42/1 (98/2%)
Glaucoma, yes/no, N (%)	27/16 (63/37%)
Aniridia
Familial, N (%)	20 (47%)
Sporadic, N (%)	23 (53%)
WAGR, N (%)	0 (0%)

Table 2 Anterior chamber angle and prior surgery in eyes with aniridia (N=86)

Open angle with glaucoma, N (%)	50/54 (93%)	P=0.32
Open angle without glaucoma, N (%)	32/32 (100%)	P<0.001
Angle closure with glaucoma, N (%)	4/54 (7%)
Prior surgery with open-angle glaucoma, N (%)	35/50 (70%)	P<0.001
Prior surgery without glaucoma, N (%)	5/32 (16%)	P=0.002
Prior surgery with angle-closure glaucoma, N (%)	4/4 (100%)

Figure 1 Anterior segment OCT images showing open- and closed-angle findings in aniridia patients. (A) A 12-year-old aniridia patient with glaucoma and open-angle (arrow). (B) A 21-year-old aniridia patient with glaucoma, aphakia, and closed-angle. The asterisk shows an area of angle closure, with iris tissue appositional to the cornea. This patient was treated with lensectomy and goniotomy as an infant, and subsequently with glaucoma drainage implant.