Comparison of anterior chamber flare among different glaucoma surgeries

Figures & data

Table 1 Comparisons of subjects’ demographic data, best-corrected visual acuity, intraocular pressure, medication, and anterior chamber flare among three surgical groups

	µLOT	LEC	EXP	p-value
Numbers
Subjects/Eyes	25/38	10/12	54/75
Age (years)
Mean ± SD	55.4.0±12.4	58.8±8.1	59.8±8.0	0.1533a
95% CI	50.2–60.5	53.0–64.6	57.7–62.0
Sex, n (%)
Male	16 (64)	8 (80)	31 (57)	0.3876b
Female	9 (36)	2 (20)	23 (43)
Eye, n (%)
Right	20 (53)	7 (58)	37 (49)	0.8804b
Left	18 (47)	5 (42)	38 (51)
BCVA (logMAR) (mean ± SD [95% CI])				0.2108c
Preoperative	−0.04±0.08 (−0.06−−0.01)	0.36±0.48 (0.06–0.66)**	0.07±0.29 (0.00–0.14)##	0.0001a
2 weeks	−0.02±0.08 (−0.05–0.01)	0.35±0.35 (0.13–0.58)**	0.20±0.36 (0.12–0.28)##	0.0001a
1 month	−0.03±0.08 (−0.06–0.00)	0.31±0.36 (0.08–0.54)**	0.12±0.28 (0.06–0.19)**	0.0001a
3 months	−0.04±0.08 (−0.06−−0.01)	0.30±0.36 (0.07–0.53)**	0.11±0.28 (0.05–0.18)**#	0.0001a
6 months	−0.03±0.08 (−0.06−−0.01)	0.29±0.36 (0.06–0.52)**	0.13±0.32 (0.06–0.20)*	0.0007a
IOP (mmHg) (mean ± SD [95% CI])				<0.0001c
Preoperative	18.8±5.2 (17.1–20.5)	20.1±7.9 (15.1–25.1)	18.1±6.1 (16.7–19.5)	0.5417a
2 weeks	14.9±4.4 (13.4–16.4)	8.8±4.7 (5.9–11.8)**	8.3±4.1 (7.4–9.3)**	<0.0001a
1 month	14.5±3.3 (13.4–15.6)	8.2±3.4 (6.0–10.3)**	9.4±3.6 (8.5–10.2)**	<0.0001a
3 months	14.2±3.1 (13.2–15.2)	8.3±1.9 (7.1–9.5)**	10.3±6.2 (8.9–11.7)**	0.0002a
6 months	14.2±2.8 (13.3–15.19	9.0±3.7 (6.6–11.4)**	10.3±3.9 (9.4–11.2)**	<0.0001a
Medication (mean ± SD [95% CI])				<0.0001c
Preoperative	3.5±0.9 (3.2–3.8)	3.6±0.8 (3.1–4.1)	3.5±0.8 (3.4–3.7)	0.9769a
2 weeks	2.8±0.7 (2.6–3.1)	0±0**	0±0**	<0.0001a
1 month	2.8±0.7 (2.6–3.1)	0.3±0.9 (−0.3–0.8)**	0±0**	<0.0001a
3 months	3.0±0.7 (2.7–3.29	0.3±0.9 (−0.3–0.8)**	0.2±0.7 (0.0–0.3)**	<0.0001a
6 months	3.1±0.8 (2.8–3.3)	0.5±1.2 (−0.2–1.2)**	0.6±1.2 (0.3–0.8)**	<0.0001a
AC flare (pc/msec) (mean ± SD [95% CI])				0.0004c
Preoperative	8.1±2.7 (7.3–9.0)	11.0±8.1 (7.2–14.9)	8.7±4.4 (7.7–9.7)	0.1129a
2 weeks	33.6±52.8 (16.2–51.0)	26.5±29.3 (7.9–45.1)	15.7±19.9 (11.1–20.3)**	0.0316a
1 month	9.9±4.1 (8.6–11.2)	11.5±4.5 (8.6–14.3)	9.3±5.8 (8.0–10.6)	0.4044a
3 months	9.1±4.2 (7.7–10.5)	10.8±3.7 (8.4–13.2)	8.4±4.4 (7.5–9.4)	0.1946a
6 months	7.9±2.0 (7.3–8.6)	12.0±6.1 (8.1–15.8)*	8.7±5.4 (7.5–10.0)	0.0386a

Notes: The p-values were calculated among the three glaucoma surgeries by one-way analysis of variance for the continuous variables (A) or by the chi-square test for the categorical variables (B). The changes in BCVA, IOP, medication, and AC flare during the postoperative periods are tested by mixed-effect regression model (C). The post-hoc Student’s t-test was performed between each pair of surgical groups. * And ** Indicate significance levels of 5% and 1%, respectively, against the µLOT group; and the # and ## indicate significance levels of 5% and 1%, respectively, against the LEC group. In the post-hoc test, based on Bonferroni’s method to correct multiple comparisons, p<0.0167 and p<0.0033 are considered significance levels of 5% (* or #) and 1% (** or ##), respectively.

Abbreviations: µLOT, microhook ab interno trabeculotomy; LEC, trabeculectomy; EXP, EX-PRESS shunt; SD, standard deviation; 95% CI, 95% confidence interval; BCVA, best-corrected visual acuity; logMAR, logarithm of the minimum angle of resolution; IOP, intraocular pressure; Medication, number of antiglaucoma medication; AC, anterior chamber; and pc, photon counts.