Figures & data
Figure 1 Infrared meibography for meibomian gland imaging. Arrows point to the glands of the lower eyelid when normal and truncated. The eyelid is everted with a Korb meibomian gland evaluator.
![Figure 1 Infrared meibography for meibomian gland imaging. Arrows point to the glands of the lower eyelid when normal and truncated. The eyelid is everted with a Korb meibomian gland evaluator.](/cms/asset/e71ebe52-80d0-4491-9a39-fc1dbf2999b2/doph_a_12176509_f0001_b.jpg)
Figure 2 Range of eyelid skin pigmentation in our patient population and representative eyelid slit-lamp images with pigmentation analysis method. Yellow square approximates the area of RGB pixel analysis. Eyelid margin vascularization was identified at the lid margin (*) in downgaze images. The bottom-right image is an example of a subject in which eyelid margin vascularization is present.
Abbreviation: RGB, red/green/blue pixel analysis.
![Figure 2 Range of eyelid skin pigmentation in our patient population and representative eyelid slit-lamp images with pigmentation analysis method. Yellow square approximates the area of RGB pixel analysis. Eyelid margin vascularization was identified at the lid margin (*) in downgaze images. The bottom-right image is an example of a subject in which eyelid margin vascularization is present.Abbreviation: RGB, red/green/blue pixel analysis.](/cms/asset/5134dc98-8ffb-473c-8289-b0e392afa3cc/doph_a_12176509_f0002_c.jpg)
Figure 3 Eyelid pigmentation compared to other subject parameters. Other parameters evaluated include: (A) meibography score evaluating for gland truncation/dropout (normal =10); (B) Schirmer’s tear production (normal≥10 mm); (C) dry eye symptoms score using the SANDE visual analogue scale; (D) presence or absence of vascularization; (E) Meibum quality (open symbol = standard pressure applied with the Korb evaluator, solid symbol = increased pressure applied with the Korb evaluator); and (F) diagnosis of MGD.
Abbreviations: SANDE, Symptom Assessment iN Dry Eye questionnaire; RGB, red/green/blue pixel analysis; MGD, Meibomian gland dysfunction.
![Figure 3 Eyelid pigmentation compared to other subject parameters. Other parameters evaluated include: (A) meibography score evaluating for gland truncation/dropout (normal =10); (B) Schirmer’s tear production (normal≥10 mm); (C) dry eye symptoms score using the SANDE visual analogue scale; (D) presence or absence of vascularization; (E) Meibum quality (open symbol = standard pressure applied with the Korb evaluator, solid symbol = increased pressure applied with the Korb evaluator); and (F) diagnosis of MGD.Abbreviations: SANDE, Symptom Assessment iN Dry Eye questionnaire; RGB, red/green/blue pixel analysis; MGD, Meibomian gland dysfunction.](/cms/asset/1009256a-942c-46d8-b1d4-826fdf6e74fa/doph_a_12176509_f0003_b.jpg)
Table 1 Sensitivity and specificity of using vascularization alone to diagnose MGD in all subjects, and split around the median pigmentation