Clinical Courses Of Corneal Endothelial Dysfunction Due To Gomphocarpus physocarpus Milky Latex-Induced Injury: A Case Series

Figures & data

Figure 1 A photograph of Gomphocarpus physocarpus fruits. Inflated fruits of Gomphocarpus physocarpus have a characteristic balloon-like shape. The fruit is approximately 5 cm long and wide and it contains numerous small black seeds.

Table 1 Patients’ Basic Characteristics And Clinical Findings On The First Visit

Case	1	1	2	3	4
Sex	Female	Female	Female	Male	Female
Age	86	86	71	74	83
Side	Right	Left	Left	Right	Right
Best-corrected visual acuity on first visit (logMAR)	0.30	0.097	0.15	0.52	0.045
Intraocular pressure (mmHg)	17	17	10	13	10
Corneal endothelial density (/mm^2)	2535	2500	3013	2661	2710
Central corneal thickness (μm)	820	652	567	713	747
Hyperemia	−	−	+	−	+
Corneal epithelial defect	−	−	−	−	−
Blepharitis	−	−	−	−	−
Cells in anterior chamber	Trace	Trace	−	+	−
Flare in anterior chamber	+	+	−	−	−
Fundus	No abnormality	No abnormality	No abnormality	No abnormality	No abnormality
Lens	Pseudophakia	Pseudophakia	Phakia	Phakia	Pseudophakia
Others	Pseudoexfoliation	Pseudoexfoliation	Keratic precipitates	None	None

Figure 2 The changes in central corneal thickness of the patients. Increased central corneal thickness was observed at the first visit and it gradually decreased to approximately less than 600 μm 2 weeks after the injury.

Figure 3 The changes in corneal endothelial cell density of the patients. Corneal endothelial cell density was higher than 2000 cells/mm² in all patients at the first visit and during the observation period.

Figure 4 Clinical findings of the anterior segment at the first visit for case 1. (A, C) Photograph of the anterior segment of the right (A) and left (C) eyes. Folds of Descemet’s membrane were observed. (B, D) Photograph of the cornea of the right (B) and left (D) eyes after the use of fluorescein. Superficial punctual keratitis was bilaterally observed but corneal epithelial defect was not observed.

Figure 5 Clinical findings of the anterior segment at the first visit for case 4. (A) Photograph of the anterior segment of the right eye. Hyperemia was not observed. (B) Photograph of slit-lamp examination of the right eye. Folds of Descemet’s membrane were observed. (C) Photograph of the cornea after the use of fluorescein. Corneal epithelial defect was not observed. (D) Optical coherence tomography image of the anterior segment. Paracentral corneal thickness was 625 μm and corneal edema was observed. (E) Photograph of the anterior segment after the treatment. The folds of Descemet’s membrane disappeared.