The first report on intermediate-term outcome of Ex-PRESS^® glaucoma filtration device implanted under scleral flap in Japanese patients

Figures & data

Table 1 Background factors of groups

	Ex-PRESS group (ten eyes)	TE group (eleven eyes)	Pvalue
Type of glaucoma	8 POAG eyes and 2 SG eyes	9 POAG eyes and 2 SG eyes	1.0^a
Age	64.2 ± 17.4	71.3 ± 11.5	0.28^b
Sex (M:F)	8:2	5:6	0.18^a
Eyes with previous intraocular surgeries	0.70 ± 0.82	0.91 ± 0.83	0.57^c
Stage (by Aulhorn-Greve’s classification)	4.8 ± 0.63	4.1 ± 0.94	0.10^c
Eyes with cataract–glaucoma combined surgery	3 eyes	3 eyes	1.0^a

Notes: Values mean ± SD;

a Fisher’s exact test;

b Unpaired t-test;

c Mann–Whitney U-test.

Abbreviations: POAG, primary open-angle glaucoma; SG, secondary glaucoma.

Table 2 Early postoperative complications (1 week after surgery)

	Ex-PRESS group (ten eyes)	TE group (eleven eyes)	Pvalue^a
Shallow anterior chambers	1	2	1.0
Hypotony (5 mmHg or lower)	1	4	0.31
Choroidal detachment	2	4	0.64
Hyphema	0	2	0.48
Fall in visual acuity (by 2 or more decimal levels)	1	5	0.15

Note:

a Fisher’s exact test.

Figure 1 Time-course trends in intraocular pressure (IOP) of the Ex-PRESS Group and the conventional trabeculectomy (TE) Group.

Notes: Data are expressed as mean ± SEM for ten and eleven eyes, respectively. There was no significant difference between the groups at any time-point (unpaired t-test).

Figure 2 Kaplan–Meier survival analysis after implantation of the Ex-PRESS device under a scleral flap (Ex-PRESS Group, solid line) or conventional trabeculectomy (TE Group, dashed line). The success rate was 100% (Ex-PRESS Group) and 81.8% (TE Group) at 1 year postoperatively (P = 0.167, log-rank test).

Figure 3 Time-course trends in visual acuity of the Ex-PRESS Group (•) and the conventional trabeculectomy (TE) Group (○) excluding cases with additional cataract surgery.

Notes: Data are expressed as mean ± SEM for seven and eight eyes, respectively. Each asterisk indicates a significant difference compared with preoperative level (*P < 0.05, paired t-test).

Table 3 Postoperative care and treatment (1 year after surgery)

	Ex-PRESS group (ten eyes)	TE group (eleven eyes)	Pvalue
Laser suture lysis	30% (3)	64% (7)	0.20^a
Needling	20% (2)	30% (3)	1.0^a
Number of glaucoma eyedrop administration	0.6 ± 1.1	1.4 ± 1.2	0.11^b

Notes:

a Fisher’s exact test;

b Mann–Whitney U-test.

Table 4 Late postoperative complications (1 year after surgery)

	Ex-PRESS group (ten eyes)	TE group (eleven eyes)	Pvalue^a
Progression of stage (by Aulhorn-Greve’s classification)	0	4	0.09
Bleb leak	0	1	1.0
Endophthalmitis	0	1	1.0

Note:

a Fisher’s exact test.