Figures & data
Table 1 Effect of pyruvate eye drops on the development of cataract in diabetic mice was assessed by ophthalmoscopy after mydriasis. As shown, the number of cataracts in the untreated diabetic group was significantly higher as compared with the pyruvate-treated group. Duration of diabetes was 6 weeks
Figure 1 Levels of glutathione in the diabetic mouse lens. Glutathione was determined in the acid extract of the tissue as described in the text to estimate the effect of topical pyruvate.
Note: Data represent mean ± standard deviation (n = 6; P < 0.001) between normal and untreated diabetic groups as well as between the untreated and pyruvate-treated diabetic groups.
Figure 2 Effect of pyruvate eye drops on the extent of protein glycation in the diabetic mouse lens: Glycated proteins were determined in the aqueous lens extract by affinity chromatography using a boronate column.
Note: Results represent mean ± standard deviation (n = 6, P < 0.001) between normal and untreated diabetic groups as well as between untreated and pyruvate-treated diabetic groups.
