Corneal Hysteresis as a Biomarker of Glaucoma: Current Insights

Figures & data

Table 1 List of Corneal Hysteresis Resources

Souce	Study/Article	Authors	Journal
1.	The Ocular Hypertension Treatment Study^Citation1	Gordon MO	Arch Ophthalmol
2.	A Prospective Longitudinal Study to Investigate Corneal Hysteresis as a Risk Factor for Predicting Development of Glaucoma^Citation2	Susanna CN, Diniz-Filho A, Daga FB, et al.	Am J Ophthalmol
3.	Corneal hysteresis in patients with glaucoma-like optic discs, ocular hypertension and glaucoma^Citation3	Murphy ML, Pokrovskaya O, Galligan M, O’Brien C	BMC Ophthalmol
4.	Corneal Biomechanics and Visual Field Progression in Eyes with Seemingly Well-Controlled Intraocular Pressure^Citation4	Susanna BN, Ogata NG, Jammal AA, Susanna CN, Berchuck SI, Medeiros FA.	Ophthalmology
5.	Central Corneal Thickness and Corneal Hysteresis Associated With Glaucoma Damage^Citation5	Congdon NG, Broman AT, Bandeen-Roche K, Grover D, Quigley HA.	Am J Ophthalmol
6.	Corneal Hysteresis as a Risk Factor for Glaucoma Progression: A Prospective Longitudinal Study^Citation6	Medeiros FA, Meira-Freitas D, Lisboa R, Kuang TM, Zangwill LM, Weinreb RN.	Ophthalmology
7.	The heritability of corneal hysteresis and ocular pulse amplitude:  a twin study^Citation7	Carbonaro F, Andrew T, Mackey DA, et al	Ophthalmology
8.	Lower corneal hysteresis is associated with more rapid glaucomatous visual field progression^Citation8	De Moraes CV, Hill V, Tello C, Liebmann JM, Ritch R	J Glaucoma
9.	Corneal Hysteresis and Progressive Retinal Nerve Fiber Layer Loss in Glaucoma^Citation9	Zhang C, Tatham AJ, Abe RY, et al.	Am J Ophthalmol
10.	Corneal biomechanics: from theory to practice^Citation10	Roberts CJ, Liu J
11.	Assessment of Corneal Hysteresis Measured by the Ocular Response Analyzer as a Screening Tool in Patients with Glaucoma^Citation11	Schweitzer JA, Ervin M, Berdahl JP	Clin Ophthalmology
12.	Significance of corneal biomechanical properties in patients with progressive normal-tension glaucoma^Citation12	Park JH, Jun RM, Choi KR	Br J Ophthalmol
13.	The relationship between corneal hysteresis and the magnitude of intraocular pressure reduction with topical prostaglandin therapy^Citation13	Agarwal DR, Ehrlich JR, Shimmyo M, Radcliffe NM	Br J Ophthalmol
14.	Effect of topical prostaglandin analogues on corneal hysteresis^Citation14	Bolívar G, Sánchez-Barahona C, Teus M, et al.	Acta Ophthalmol.
15.	The impact of chronic use of prostaglandin analogues on the biomechanical properties of the cornea in patients with primary open-angle glaucoma^Citation15	Meda R, Wang Q, Paoloni D, Harasymowycz P, Brunette I	Br J Ophthalmol
16.	Effects of antiglaucoma drops on MMP and TIMP balance in conjunctival and subconjunctival tissue^Citation16	Ito T, Ohguro H, Mamiya K, Ohguro I, Nakazawa M	Invest Ophthalmol Vis Sci
17.	Prostaglandin FP agonists alter metalloproteinase gene expression in sclera^Citation17	Weinreb RN, Lindsey JD, Marchenko G, Marchenko N, Angert M, Strongin A	Invest Ophthalmol Vis Sci
18.	Laser trabeculoplasty for open-angle glaucoma: a report by the American academy of ophthalmology^Citation18	Samples JR, Singh K, Lin SC, et al.	Ophthalmology
19.	Effect of selective laser trabeculoplasty on corneal biomechanics^Citation19	Pillunat KR, Spoerl E, Terai N, Pillunat LE	Acta Ophthalmol
20.	Corneal Biomechanical Changes Following Trabeculectomy, Phaco-trabeculectomy, Ahmed Glaucoma Valve Implantation and Phacoemulsification^Citation20	Pakravan M, Afroozifar M, Yazdani S	J Ophthalmic Vis Res
21.	Corneal Biomechanical Changes After Trabeculectomy and the Impact on Intraocular Pressure Measurement^Citation21	Pillunat KR, Spoerl E, Terai N, Pillunat LE	J Glaucoma
22.	Corneal biomechanics predict the outcome of selective laser trabeculoplasty in medically uncontrolled glaucoma^Citation22	Hirneiß C, Sekura K, Brandlhuber U, Kampik A, Kernt M	Graefes Arch Clin Exp Ophthalmol
23.	Factors associated with topographic changes of the optic nerve head induced by acute intraocular pressure reduction in glaucoma patients^Citation23	Prata TS, Lima VC, de Moraes CG, et al.	Eye (Lond)
24.	Lower corneal hysteresis in glaucoma patients with acquired pit of the optic nerve (APON)^Citation24	Bochmann F, Ang GS, Azuara-Blanco A	Graefes Arch Clin Exp Ophthalmol.
25.	Association between corneal biomechanical properties and optic nerve head morphology in newly diagnosed glaucoma patients^Citation25	Prata TS, Lima VC, Guedes LM, et al.	Clin Exp Ophthalmol
26.	Relationship between corneal hysteresis and lamina cribrosa displacement after medical reduction of intraocular pressure^Citation26	Lanzagorta-Aresti A, Perez-Lopez M, Palacios-Pozo E, Davo-Cabrera J	Br J Ophthalmol
27.	Relationship between corneal hysteresis and optic nerve parameters measured with spectral domain optical coherence tomography^Citation27	Vu DM, Silva FQ, Haseltine SJ, Ehrlich JR, Radcliffe NM	Graefes Arch Clin Exp Ophthalmol
28.	Association of Corneal Hysteresis With Lamina Cribrosa Curvature in Primary Open Angle Glaucoma^Citation28	Lee KM, Kim TW, Lee EJ, Girard MJA, Mari JM, Weinreb RN	Invest Ophthalmology Vis Sci
29.	Corneal hysteresis but not corneal thickness correlates with optic nerve surface compliance in glaucoma patients^Citation29	Wells AP, Garway-Heath DF, Poostchi A, Wong T, Chan KC, Sachdev N	Invest Ophthalmol Vis Sci

Figure 1 Ocular response analyzer (ORA) reading. P1 indicates the air-jet pressure when the cornea undergoes an inward applanation and P2 is the pressure at which the cornea bends back to normal configuration. Corneal hysteresis is defined by P1-P2.¹⁰ Figure courtesy of Reichart Inc., Depew, NY, USA.

Figure 2 Relationship between predictive rates of VFI change, IOP, and CH, 2013. Notes: Reprinted from Ophthalmology: Journal of the American Academy of Ophthalmology, Vol 120(8), Medeiros FA, Meira-Freitas D, Lisboa R, Kuang TM, Zangwill LM, Weinreb RN, Corneal hysteresis as a risk factor for glaucoma progression: a prospective longitudinal study, Pages No.1533–1540, Copyright 2013, with permission from Elsevier.⁶

Figure 3 Cumulative probability of glaucoma development in glaucoma suspect eyes with CH equal or greater than 10.2, and in those with CH lesser than 10.2 mmHg. Notes: Reprinted from American Journal of Ophthalmology, Vol 187, Susanna CN, Diniz-Filho A, Daga FB, et al, A prospective longitudinal study to investigate corneal hysteresis as a risk factor for predicting development of glaucoma, Pages No.148–152, Copyright 2018, with permission from Elsevier.²

Gordon MO, Beiser JA, Brandt JD, et al. The ocular hypertension treatment study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002;120(6):714–720; discussion 829–730. doi:10.1001/archopht.120.6.714

 Google Scholar

Susanna CN, Diniz-Filho A, Daga FB, et al. A prospective longitudinal study to investigate corneal hysteresis as a risk factor for predicting development of glaucoma. Am J Ophthalmol. 2018;187:148–152. doi:10.1016/j.ajo.2017.12.018

 PubMed Web of Science ®Google Scholar

Murphy ML, Pokrovskaya O, Galligan M, O’Brien C. Corneal hysteresis in patients with glaucoma-like optic discs, ocular hypertension and glaucoma. BMC Ophthalmol. 2017;17(1):1. doi:10.1186/s12886-016-0396-9

 PubMed Web of Science ®Google Scholar

Susanna BN, Ogata NG, Jammal AA, et al. Visual field progression in eyes with seemingly well-controlled intraocular pressure. Ophthalmology. 2019;126(12):1640–1646. doi:10.1016/j.ophtha.2019.07.023

 Web of Science ®Google Scholar

Congdon NG, Broman AT, Bandeen-Roche K, Grover D, Quigley HA. Central corneal thickness and corneal hysteresis associated with glaucoma damage. Am J Ophthalmol. 2006;141(5):868–875. doi:10.1016/j.ajo.2005.12.007

 PubMed Web of Science ®Google Scholar

Medeiros FA, Meira-Freitas D, Lisboa R, Kuang TM, Zangwill LM, Weinreb RN. Corneal hysteresis as a risk factor for glaucoma progression: a prospective longitudinal study. Ophthalmology. 2013;120(8):1533–1540. doi:10.1016/j.ophtha.2013.01.032

 PubMed Web of Science ®Google Scholar

Carbonaro F, Andrew T, Mackey DA, et al. The heritability of corneal hysteresis and ocular pulse amplitude: a twin study. Ophthalmology. 2008;115:1545-1549

 Google Scholar

De Moraes CVG, Hill V, Tello C, Liebmann JM, Ritch R. Lower corneal hysteresis is associated with more rapid glaucomatous visual field progression. J Glaucoma. 2012;21(4):209–213. doi:10.1097/IJG.0b013e3182071b92

 PubMed Web of Science ®Google Scholar

Zhang C, Tatham AJ, Abe RY, et al. Corneal hysteresis and progressive retinal nerve fiber layer loss in glaucoma. Am J Ophthalmol. 2016;166:29–36. doi:10.1016/j.ajo.2016.02.034

 PubMed Web of Science ®Google Scholar

Roberts CJ, Liu J. Corneal Biomechanics: From Theory to Practice. 1 ed. Amsterdam NM: Kugler Publications; 2016.

 Google Scholar

Schweitzer JA, Ervin M, Berdahl JP. Assessment of corneal hysteresis measured by the ocular response analyzer as a screening tool in patients with glaucoma. Clin Ophthalmol. 2018;12:1809–1813. doi:10.2147/OPTH.S168032

 Web of Science ®Google Scholar

Park JH, Jun RM, Choi KR. Significance of corneal biomechanical properties in patients with progressive normal-tension glaucoma. Br J Ophthalmol. 2015;99(6):746–751. doi:10.1136/bjophthalmol-2014-305962

 Web of Science ®Google Scholar

Agarwal DR, Ehrlich JR, Shimmyo M, Radcliffe NM. The relationship between corneal hysteresis and the magnitude of intraocular pressure reduction with topical prostaglandin therapy. Br J Ophthalmol. 2012;96(2):254–257. doi:10.1136/bjo.2010.196899

 PubMed Web of Science ®Google Scholar

Bolívar G, Sánchez-Barahona C, Teus M, et al. Effect of topical prostaglandin analogues on corneal hysteresis. Acta Ophthalmol. 2015;93(6):e495–e498. doi:10.1111/aos.12689

 PubMed Web of Science ®Google Scholar

Meda R, Wang Q, Paoloni D, Harasymowycz P, Brunette I. The impact of chronic use of prostaglandin analogues on the biomechanical properties of the cornea in patients with primary open-angle glaucoma. Br J Ophthalmol. 2017;101(2):120–125. doi:10.1136/bjophthalmol-2016-308432

 PubMed Web of Science ®Google Scholar

Ito T, Ohguro H, Mamiya K, Ohguro I, Nakazawa M. Effects of antiglaucoma drops on MMP and TIMP balance in conjunctival and subconjunctival tissue. Invest Ophthalmol Vis Sci. 2006;47(3):823–830. doi:10.1167/iovs.05-0902

 Web of Science ®Google Scholar

Weinreb RN, Lindsey JD, Marchenko G, Marchenko N, Angert M, Strongin A. Prostaglandin FP agonists alter metalloproteinase gene expression in sclera. Invest Ophthalmol Vis Sci. 2004;45(12):4368–4377. doi:10.1167/iovs.04-0413

 PubMed Web of Science ®Google Scholar

Samples JR, Singh K, Lin SC, et al. Laser trabeculoplasty for open-angle glaucoma: a report by the american academy of ophthalmology. Ophthalmology. 2011;118(11):2296–2302. doi:10.1016/j.ophtha.2011.04.037

 PubMed Web of Science ®Google Scholar

Pillunat KR, Spoerl E, Terai N, Pillunat LE. Effect of selective laser trabeculoplasty on corneal biomechanics. Acta Ophthalmol. 2016;94(6):e501–e504. doi:10.1111/aos.12947

 Web of Science ®Google Scholar

Pakravan M, Afroozifar M, Yazdani S. Corneal biomechanical changes following trabeculectomy, phaco-trabeculectomy, ahmed glaucoma valve implantation and phacoemulsification. J Ophthalmic Vis Res. 2014;9(1):7–13.

 Google Scholar

Pillunat KR, Spoerl E, Terai N, Pillunat LE. Corneal biomechanical changes after trabeculectomy and the impact on intraocular pressure measurement. J Glaucoma. 2017;26(3):278–282. doi:10.1097/IJG.0000000000000595

 Web of Science ®Google Scholar

Hirneiß C, Sekura K, Brandlhuber U, Kampik A, Kernt M. Corneal biomechanics predict the outcome of selective laser trabeculoplasty in medically uncontrolled glaucoma. Graefes Arch Clin Exp Ophthalmol. 2013;251(10):2383–2388. doi:10.1007/s00417-013-2416-2

 PubMed Web of Science ®Google Scholar

Prata TS, Lima VC, de Moraes CG, et al. Factors associated with topographic changes of the optic nerve head induced by acute intraocular pressure reduction in glaucoma patients. Eye (Lond). 2011;25(2):201–207. doi:10.1038/eye.2010.179

 Web of Science ®Google Scholar

Bochmann F, Ang GS, Azuara-Blanco A. Lower corneal hysteresis in glaucoma patients with acquired pit of the optic nerve (APON). Graefes Arch Clin Exp Ophthalmol. 2008;246(5):735–738. doi:10.1007/s00417-007-0756-5

 Web of Science ®Google Scholar

Prata TS, Lima VC, Guedes LM, et al. Association between corneal biomechanical properties and optic nerve head morphology in newly diagnosed glaucoma patients. Clin Exp Ophthalmol. 2012;40(7):682–688.

 Web of Science ®Google Scholar

Lanzagorta-Aresti A, Perez-Lopez M, Palacios-Pozo E, Davo-Cabrera J. Relationship between corneal hysteresis and lamina cribrosa displacement after medical reduction of intraocular pressure. Br J Ophthalmol. 2017;101(3):290–294. doi:10.1136/bjophthalmol-2015-307428

 Web of Science ®Google Scholar

Vu DM, Silva FQ, Haseltine SJ, Ehrlich JR, Radcliffe NM. Relationship between corneal hysteresis and optic nerve parameters measured with spectral domain optical coherence tomography. Graefes Arch Clin Exp Ophthalmol. 2013;251(7):1777–1783. doi:10.1007/s00417-013-2311-x

 Web of Science ®Google Scholar

Lee KM, Kim TW, Lee EJ, Girard MJA, Mari JM, Weinreb RN. Association of corneal hysteresis with lamina cribrosa curvature in primary open angle glaucoma. Invest Ophthalmol Vis Sci. 2019;60(13):4171–4177. doi:10.1167/iovs.19-27087

 PubMed Web of Science ®Google Scholar

Wells AP, Garway-Heath DF, Poostchi A, Wong T, Chan KC, Sachdev N. Corneal hysteresis but not corneal thickness correlates with optic nerve surface compliance in glaucoma patients. Invest Ophthalmol Vis Sci. 2008;49(8):3262–3268. doi:10.1167/iovs.07-1556

 PubMed Web of Science ®Google Scholar