Improved Tear Film Stability in Patients with Dry Eye After Hyaluronic Acid and Galactoxyloglucan Use

Figures & data

Table 1 Baseline, 1-Week, and 1-Month Clinical and Demographic Characteristics of the Participants

	Baseline	1 Week	1 Month
Age (years)	63.85 ± 13.15
Sex (M:F)	2:18
Schirmer I test (mm/5 min)	7.53 ± 4.69
FBUT (s)	4.80 ± 2.14	7.20 ± 2.51 P = 0.000	8.73 ± 2.26 P = 0.000
TMH (mm)	0.27 ± 0.10	0.33 ± 0.13 P =0.002	0.33 ± 0.15 P =0.001
NIKBUT-first (s)	6.20 ± 4.59	8.35 ± 5.26 P = 0.014	9.52 ± 5.92 P = 0.003
NIKBUT-average (s)	10.02 ± 5.72	12.12 ± 5.52 P = 0.007	13.22 ± 5.30 P = 0.002
Conjunctival hyperemia	1.36 ± 0.54	1.19 ± 0.45 P = 0.08	1.12 ± 0.48 P = 0.008
Oxford score	2.68 ± 2.53	2.03 ± 1.76 P = 0.025	0.95 ± 1.78 P = 0.000
OSDI score	37.58 ± 17.66	29.69 ± 18.67 P = 0.000	16.41± 8.56 P = 0.000

Note: P-values represent the differences between the baseline and the subsequent timepoints.

Abbreviations: M, male; F, female; FBUT, fluorescein break-up time; TMH, tear meniscus height; NIKBUT, non-invasive Keratograph tear break-up time; OSDI, Ocular Surface Disease Index.

Figure 1 Comparison of the mean values of non-invasive Keratograph 5M first tear break-up time and non-invasive Keratograph average break-up time at the 3 visits, showing an increase at 1 week and 1 month from baseline. The asterisk (*) denotes statistical significance.

Abbreviation: NIKBUT, non-invasive Keratograph break-up time.

Figure 2 Mean hyperemia scores of all patients during the 3 visits. The asterisk (*) denotes statistical significance.

Figure 3 Mean values of the Oxford score measured during slit-lamp examination (top panel) and the Ocular Surface Disease Index scores (bottom panel) recorded during the study, showing a decrease at 1 week and 1 month from baseline. The asterisk (*) denotes statistical significance.

Abbreviation: OSDI, Ocular Surface Disease Index.

Figure 4 Comparison of the mean values of non-invasive Keratograph 5M first tear break-up time and non-invasive Keratograph average break-up time measured during the first 120 min after instillation of the drop. There was an initial increase in both parameters at 15 min, followed by a gradual decrease after 30 min. The asterisk (*) denotes statistical significance.

Abbreviation: NIKBUT, Non-invasive Keratograph break-up time.