The Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery

Figures & data

Figure 1 Preoperative biometry performed after 28 days of lifitegrast predicted the 1 month postoperative outcome with significantly greater accuracy than preoperative biometry measured before lifitegrast treatment.

Figure 2 Preoperative total corneal higher order aberrations improved in a significant majority of patients treated with lifitegrast before surgery.

Table 1 Secondary Outcome Measures Showed Significant Improvement for All Measures at All Time Points

	Baseline	Preoperative After Lifitegrast	Postoperative Taking Lifitegrast	P value (Paired t-Test)
SPEED Score (mean ± stdev)	8.1 ± 6.6	6.3 ± 4.9	4.0 ± 3.2	<0.0004
Patients with grade 1 corneal staining	60 (58%)	52 (63%)	21 (42%)	<0.00001
TBUT (sec)	5.1 ± 1.7	7.8 ± 2.6	8.5 ± 2.5	<0.0001
Patients with conjunctival erythema (Schulze Scale) ≥ 20	65 (63%)	26 (31%)	8 (20%)	<0.0001

Figure 3 SPEED scores improved significantly after initial lifitegrast treatment and continued to improve following ongoing lifitegrast treatment postoperatively.