A Retrospective Data Review Confirms That Topical Preservative-Free Hydrocortisone Improves Inflammation in Dry Eye Disease

Figures & data

Table 1 Patient Demographic and DED Data at Day 01 (Mean Values)

Parameters	Value
Number of patients (n, %)
Women	13 (8.66%)
Men	2 (13.33%)
Age (Mean±SD, years)
Women	51±5 years
Man	53±4 years
CPTFT (Mean±SD, µm)
Right eye	20.93±5.01
Left eye	20.4±4.22
FTBUT (Mean±SD, sec)
Right eye	4.33±1.5
Left eye	4.33±1.18
Schirmer test (Mean±SD, mm)
Right eye	8.26±3.81
Left eye	8.4±4.38
OSDI score	24.53±4.39
Corneal grading (Mean±SD, Oxford schema)
Right eye	2.8±0.94
Left eye	3.0±0.65
Overall IOP (Mean±SD, mmHg)	15.0+2.0

Abbreviations: CPTFT, central precorneal tear film; FTBUT, fluorescein tear breakup; OSDI, ocular surface disease index, SD, standard deviation, sec, seconds.

Figure 1 Mean results for central precorneal tear film thickness, fluorescein tear breakup time, Schirmer test, ocular surface disease index and corneal grading at Day 0 and Day 15. *p=0.000015, **p=0.0003, ***p=0.009, ****p=0.03, *****p=0.002, ******p=0.001.

Abbreviations: CPTFT, central precorneal tear film thickness; FTBUT, fluorescein tear breakup time; OSDI, ocular surface disease index; corneal grading staining done by Oxford schema; sec, second.

Figure 2 Mean percent change in tear film thickness between Day 0 and Day 15, according to CPTFT (<24 µm or ≥24 µm) at Day 0. *p=0.004. **p=0.03. ***p=0.02.

Table 2 Correlation Coefficients of Percentages of Change in Tear Film Thickness Between the Different Tests, and p-values

	R- CPTFT	L- CPTFT	R-FTBUT	L-FTBUT	R-Sc	L-Sc	OSDI	R-OX	L-OX
R-CPTFT	1.0	0.78 (0.0003)	0.47 (0.06)	0.69 (0.03)	−0.2 (0.9)	−0.47 (0.06)	0.26 (0.32)	0.25 (0.33)	0.16 (0.52)
L-CPTFT	0.78 (0.0003)	1.0	0.16 (0.55)	0.68 (0.03)	−0.24 (0.35)	−0.37 (0.14)	0.3 (0.26)	0.25 (0.34)	0.24 (0.36)
R-FTBUT	0.47 (0.06)	0.16 (0.55)	1.0	0.23 (0.37)	0.45 (0.07)	0.07 (0.77)	0.54 (0.03)	0.42. (0.09)	0.26 (0.33)
L-FTBUT	0.69 (0.03)	0.68 (0.03)	0.23 (0.37)	1.0	−0.14. (0.59)	−0.13 (0.62)	0.32 (0.21)	0.42 (0.09)	0.40 (0.12)
R-Sc	−0.2 (0.9)	−0.24 (0.35)	0.45 (0.07)	−0.14 (0.59)	1.0	0.62 (0.09)	0.02 (0.9)	0.26 (0.32)	0.03 (0.89)
L-Sc	−0.47 (0.06)	−0.37 (0.14)	0.07 (0.77)	−0.13 (0.62)	0.62 (0.09)	1.0	0.11 (0.67)	0.23 (0.38)	0.18 (0.50)
OSDI	0.26 (0.32)	0.3 (0.26)	0.54. (0.03)	0.32 (0.21)	0.02 (0.9)	0.11 (0.67)	1.0	0.35 (0.17)	0.1 (0.68)
R-OX	0.25 (0.33)	0.25 (0.34)	0.42 (0.09)	0.42 (0.09)	0.26 (0.32)	0.23. (0.38)	0.35 (0.17)	1.0	0.69 (0.03)
L-OX	0.16 (0.52)	0.24 (0.36)	0.26 (0.33)	0.40 (0.12)	0.03 (0.89)	0.18 (0.50)	0.1 (0.68)	0.69 (0.03)	1.0

Abbreviations: R-CPTFT, right eye central precorneal tear film; L-CPTFT, left eye central precorneal tear film thickness; R-FTBUT, right eye fluorescein tear breakup; L-FTBUT, left eye fluorescein tear breakup time; R-Sc, right eye Schirmer test; L-Sc, left eye Schirmer test; OSDI, ocular surface disease index; R-Ox, corneal grading staining done by Oxford schema, right eye; L-Ox, corneal grading staining done by Oxford schema, left eye.